Flashcards in Glomerular Diseases Deck (39):
normal glomerulus what is NOT filtered out?
in tubules, what are NOT reabsorbed?
capillary lining of endothelium in glomerulus is special how?
large fenestrated endothelium
what so special about the basement membrane in glomerulus?
negatively charge Type IV collagen
3 types of cells in glomerulus are?
mesangial: contractile: stalk
what is dropsy?
severe proteinuria and you get crazy full body swelling
which protein is lost in proteinuria? how much?
albumin 3-4 g/day
why do swell in proteinuria?
not enough proteins in vessels to generate oncotic pressure of fluid back into vessels so all fluid just leaks out into tissues
3 reasons why proteins stay in glomerulus?
1. negative charged BM
2. Physical structure of Type IV collagen
3. proteins in slit membranes (Nephrin)
Finnish subpopulation have a defect in Nephrin which causes what?
protein leakage from birth in urine
What is Alport syndrome?
mutated collagen IV subtype in BM = proteinuria
4 common reasons for proteinuria?
Acute renal 'failure' refers specifically to what?
decrease GFR = reduced creatinine clearance
increased serum urea and creatinine
renal causes of acute renal failure? 4 main?
acute tubular necrosis
acute interstitial nephritis
other. eg. vascular disease
Glomerulonephritis one or group of conditions? most often due to what?
group of conditions
immune mediated: immune complex deposition
Is there Glomerulonephritis without immune complexes?
yes. rare: pauci-immune
Acute Glomerulonephritis acute or chronic?
Can be both
Acute Glomerulonephritis cause?
Chronic Glomerulonephritis cause?
what do you get if you get severe necrosis from acute Glomerulonephritis ?
What's most common form of Glomerulonephritis in Australia?
in Glomerulonephritis , how do glomeruli react?
BM new layers: spikes/protrusions
inflammatory cell arrival
How many glomeruli are affected in diffuse or global?
ALL OF THEM!
Lots of what in Acute post-infectious Glomerulonephritis ?
IgG clumps on BM
what else can cause acute Glomerulonephritis besides post strep immune complexes?
4 tools for diagnosis of Glomerulonephritis?
Glomerulonephritis in systemic lupus erythematosis histologically?
immune complex deposition in glomeruli
IgA nephropathy have immune complexes where?
immune complexes deposit where in membranous nephropathy?
outer aspect of basement membrane
What is a Crescent in the glomerulus made of?
exuded fibrin, monocytes and podocytes
are crescents specific for one form of GN?
Nope, any response to severe injury
Injury to Gl progression
sclerotic ball without capillaries
Does Glomerulonephritis resolve completely?
Which Glomerulonephritis progress to chronic?
Lupus, HIV due to continued stimulus
Does IgA nephropathy have good prognosis?
Used to be yes. Now, not so much due to immune complex deposition
Is Diabetec nephropathy due to autoimmune?
what is THE most common cause of end stage renal failure?
What renal features of early and late Diabetec nephropathy?
early: protein leakage/nephrotic syndrome
late: chronic renal failure