Glomerular Diseases Flashcards Preview

Jason's Renal Block > Glomerular Diseases > Flashcards

Flashcards in Glomerular Diseases Deck (39):
1

normal glomerulus what is NOT filtered out?

RBCs
proteins

2

in tubules, what are NOT reabsorbed?

creatinine
urea

3

capillary lining of endothelium in glomerulus is special how?

large fenestrated endothelium
podocytes

4

what so special about the basement membrane in glomerulus?

negatively charge Type IV collagen

5

3 types of cells in glomerulus are?

endothelial: lining
mesangial: contractile: stalk
epithelium: podocytes

6

what is dropsy?

severe proteinuria and you get crazy full body swelling

7

which protein is lost in proteinuria? how much?

albumin 3-4 g/day

8

why do swell in proteinuria?

not enough proteins in vessels to generate oncotic pressure of fluid back into vessels so all fluid just leaks out into tissues

9

3 reasons why proteins stay in glomerulus?

1. negative charged BM
2. Physical structure of Type IV collagen
3. proteins in slit membranes (Nephrin)

10

Finnish subpopulation have a defect in Nephrin which causes what?

protein leakage from birth in urine

11

What is Alport syndrome?

mutated collagen IV subtype in BM = proteinuria

12

4 common reasons for proteinuria?

DMII
glomerulonephritis
amyloid deposition
Nephrin deficiency

13

Acute renal 'failure' refers specifically to what?

decrease GFR = reduced creatinine clearance
increased serum urea and creatinine

14

renal causes of acute renal failure? 4 main?

acute tubular necrosis
acute glomerulonephritis
acute interstitial nephritis
other. eg. vascular disease

15

Glomerulonephritis one or group of conditions? most often due to what?

group of conditions
immune mediated: immune complex deposition

16

Is there Glomerulonephritis without immune complexes?

yes. rare: pauci-immune

17

Acute Glomerulonephritis acute or chronic?

Can be both

18

Acute Glomerulonephritis cause?

post-streptococcal GN

19

Chronic Glomerulonephritis cause?

IgA nephropathy

20

what do you get if you get severe necrosis from acute Glomerulonephritis ?

crescents

21

What's most common form of Glomerulonephritis in Australia?

IgA nephropathy

22

in Glomerulonephritis , how do glomeruli react?

BM new layers: spikes/protrusions
cell proliferation
inflammatory cell arrival

23

How many glomeruli are affected in diffuse or global?

ALL OF THEM!

24

Lots of what in Acute post-infectious Glomerulonephritis ?

neutrophils
IgG clumps on BM

25

what else can cause acute Glomerulonephritis besides post strep immune complexes?

antibiotic reaction

26

4 tools for diagnosis of Glomerulonephritis?

clinical findings
light microscopy
immunostains
electron microscopy

27

Glomerulonephritis in systemic lupus erythematosis histologically?

immune complex deposition in glomeruli

28

IgA nephropathy have immune complexes where?

mesangium

29

immune complexes deposit where in membranous nephropathy?

outer aspect of basement membrane

30

What is a Crescent in the glomerulus made of?

exuded fibrin, monocytes and podocytes

31

are crescents specific for one form of GN?

Nope, any response to severe injury

32

Injury to Gl progression

Necrotizing lesions
sclerosing lesions
sclerotic ball without capillaries

33

Does Glomerulonephritis resolve completely?

Some acute

34

Which Glomerulonephritis progress to chronic?

Lupus, HIV due to continued stimulus

35

Does IgA nephropathy have good prognosis?

Used to be yes. Now, not so much due to immune complex deposition

36

Is Diabetec nephropathy due to autoimmune?

Nope: hyperglycemia

37

what is THE most common cause of end stage renal failure?

Diabetec nephropathy

38

What renal features of early and late Diabetec nephropathy?

early: protein leakage/nephrotic syndrome
late: chronic renal failure

39

HUS/TTP, sever hypertension, scleroderma causes what?

acute endothelial injury