Tuberculosis (Resp Infection) Flashcards

1
Q

What causes tuberculosis?

A

Mycobacterium tuberculosis

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2
Q

Where is the lungs does tuberculosis principally affect?

A

The upper lobes

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3
Q

What type of granuloma forms in tuberculosis?

A

Caseating

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4
Q

What is meant by the term Gohn Focus?

A

The lesion at the primary site of a tuberculosis infection in the lungs

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5
Q

What is meant by the term primary TB?

A

Where a patient infected with mycobacterium tuberculosis becomes symptomatic

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6
Q

What is meant by the term latent TB?

A

Where bacteria become dormant within granulomas in a patient infected with mycobacterium tuberculosis

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7
Q

Can TB resolve on its own?

A

Yes, infection spontaneously resolves in 50% of cases

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8
Q

What are the risk factors for reactivation of latent TB?

A

Diabetes, homelessness, IVDU and Immunosuppression

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9
Q

What is meant by the term miliary TB?

A

When TB becomes disseminated following passage into the blood stream

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10
Q

What is meant by the term Assman Focus?

A

A secondary pulmonary TB lesion caused by spread to the lungs from initial site of infection

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11
Q

Where is TB most commonly found?

A

India, SE Asia and Africa

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12
Q

What is the general signs of TB?

A

Malaise, fever, weight loss, lymphadenopathy, night sweats

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13
Q

What is the respiratory signs of TB?

A

Productive cough, heamoptysis, SOB, +/- chest pain and hoarseness

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14
Q

What is the dermatological signs of TB?

A

Erythema nodosum

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15
Q

What is the skeletal signs of TB?

A

Bone pain, vertebral collapse

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16
Q

What is the neurological signs of TB?

A

Meningitis

17
Q

What investigations would be used to confirm a diagnosis of TB?

A

CXR, Sputum sample and Tuberculin skin test

18
Q

What CXR results would be indicative of primary TB?

A
  • Consolidation
  • Cavitating upper lobe lesions
  • Bilateral hilar lymphadenopathy
19
Q

What CXR results would be indicative of latent TB

A

Fibrosis, calcified lesions

20
Q

What sputum sample results would be indicative of TB?

A

PCR positive and Zeihl Neelson (acid fast bacilli) positive

21
Q

What does the tuberculin skin test involve?

A

Mantoux test and tes for TB exposure and BCG injection

22
Q

What antibiotics are used to treat TB?

A

Rifampacin, Isoniazid, Pyrazinamide & Ehanbutol

23
Q

What is the main side effect of Rifampacin?

A

Enzyme induction turns all body fluids orange

24
Q

What is the main side effect of Isoniazid?

A

Neuropathy

25
Q

What is the main side effect of Pyrazinamide?

A

Hepatitis and Arthralgia

26
Q

What is the main side effect of Ehanbutol?

A

Optic neuritis

27
Q

What is the general management plan for TB?

A

All four antibiotics for 2 months then Rifampacin / Isoniazide for a further 4 months

28
Q

What type of drugs are associated with the reactivation of TB?

A

Anti TNF