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Flashcards in Tuesday Groupings/Definitions/Presentations Deck (67)
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31

PV survival?

>10yrs

32

Progression of PV?

"spent phase" similar to PMF
may develop MDS or AML

33

What kills pts w/PV?

thrombosis or hemorrhage

34

What is PMF?

MPN w/bone marrow fibrosis and extramedullary hematopoiesis

35

Clinical presentation of PMF?

splenomegaly w/portal hypertension
anemia
leukoerythroblastic reaction

36

Lab findings of PMF?

teardrop cells
increased platelet count

37

BM biopsy finding of PMF?

fibrosis
clusters of atypical megakaryocytes

38

PMF stages & survival

pre-fibrotic >10 yr
fibrotic 3-7 yr

39

What may PMF pts develop/advance to?

AML

40

What is ET (essential thrombocythemia)? Survival?

proliferation of megakaryocytes
MPN
12-15yr

41

Lab results of ET?

elevated platelet count in PB (>450,000)
atypical platelets

42

BM biopsy findings of ET?

hypercellular
abnormal megakaryocytes

43

Presentation of ET?

bleeding or thrombosis

44

Lab findings of MDS?

cytopenias
dysplastic features
ring sideroblasts
multinucleated RBC precursors
hypolobated megakaryocytes

45

What are ring sideroblasts?

iron accumulation in functionally impaired mitochondria

46

Causes of ring sideroblasts?

EtOH
Drugs/Toxins

47

Does ALL or AML have auer rods?

AML

48

AML outcome?

poor

49

AML clinical findings

severe leukopenia to marked leukocytosis
coagulopathy
anemia and thrombocytopenia

50

AML labs

>20% myeloid blasts
hypercellular BM

51

AML w/t(8,21) features

granulocytic maturation
extramedullary involvement
favorable prognosis

52

AML w/inv(16) features

myelomonocytic
eosinophils w/dysplastic features
extramedullary involvement
favorable prognosis

53

AML w/t(15,17) features

atypical promyelocytes
hypergranular
reniform nuclei
sometimes prominent auer rods
leukopenia
DIC
favorable prognosis

54

AML w/t(15,17) alias?

Acute promyelocytic leukemia (APL)

55

AML w/11q23 (MLL) rearrangements features?

infantile AML
monocytic
hyperleukocytosis
extramedularry issue infiltration

56

AML w/11q23 (MLL) is t(9,11) what is prognosis?

intermediate

57

AML w/11q23 is MLL what is prognosis?

intermediate to poor prognosis

58

What does NSE stain indicate?

monocytic lineage

59

AML w/myelodysplasia-related changes features?

dysplasia
occurs w/or w/o MDS
older individuals
poor prognosis

60

Therapy-related AML and MDS causes?

chemo/radiation
alkylating agents
topoisomerase II inhibitors