Kidneys secrete renin, what does that secrete
Angiotensin 2
How is NH3 produced
Delamination of amino acids
What is NH3 converted to in liver
Urea, uric acid and creatinine
Kidneys are inside or outside peritoneal cavity
Outside (retroperitoneal)
Kidney coverings
Renal fascia, perirenal fat capsule, fibrous capsule
How much blood does kidneys filter
180 L
What is the glomerulus
A capillary bed
Renal tubules
PCT, nephron loop, DCT, collecting duct
PCT histology and function
Simple cuboidal with microvilli, réabsorption
Nephron loop
Descending and ascending limbs, thin and thick segment
Thin segment permeable to
Water NOT salts
Thick segment permeable to
salt NOT water
Collecting duct role
Receives fluid from DCT and concentration of urine
Cortical nephrons
Short loops
Juxtamedullary nephrons
Long loops responsible for creating salt gradient
Steps of urine formation
Glomerular filtration, tubular réabsorption and secretion and water conservation
Filtration membrane has 3 barriers
Fenestrated endothelium of capillary, basement membrane, filtration slits between podocytes
Arterial end net filtration pressure?
10 mmHg
150 L filtrate - male or female
Female
If GFR too high
Dehydration occurs
GFR too low
High BP
Granule cells secrete
Renin (to increase BP)
Macula densa
Group of cells on the nephron loop that monitor filtrate composition
Order of arteries from renal artery
Renal a. Segmental a. Interlobar a. Arcuate a. Cortical radiate a. Afferent a.