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Pharm 1 > Urinary drugs > Flashcards

Urinary drugs Flashcards

1
Q

What is the most common cause of transient urge incontinence

A

cystitis

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2
Q

What is the MOA of urge incontinence drugs

A

block acetylcholine action on the bladder and diminish detrusor muscle contraction

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3
Q

What drug class is oxybutynin (ditropan)

A

anticholinergic medication

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4
Q

what is the MOA of oxybutynin

A

Competitive antagonism of M3 subtype of the muscarinic acetylcholine receptor

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5
Q

What are the side effects of oxybutynin

A

dry mouth, dry eyes, less sweat, blurred vision, drowsiness, dizziness

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6
Q

what drug class is Tolterodine/ Detrol

A

anticholinergic

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7
Q

What drug class is imipramine (tofranil)

A

tricyclic antidepressant

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8
Q

What is the MOA of imipramine (tofranil)

A

Blocks reuptake of serotonin and norepinephrine and appears to diminish acetylcholine uptake in smooth muscle

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9
Q

What are side effects of imipramine (tofranil)

A

black box warning about increased risk for suicidal ideation and suicide.

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10
Q

What happens with imipramine over dose

A

death due to heart block can occur

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11
Q

What is the MOA of tolterodine (detrol)

A

Competitive antagonism of M2 and M3 subtypes of the muscarinic acetylcholine receptor

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12
Q

Which urinary drugs have a potential for interactions with drugs metabolized by cytochrome P450

A

tolterodine and oxybutynin

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13
Q

What drug class is Tamsulosin (flomax)

A

a1 receptor antagonist

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14
Q

What is the MOA of tamsulosin (flomax)

A

Smooth muscle relaxation via alpha adrenergic antagonism.

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15
Q

What drug class is finasteride (proscar)

A

5 alpha reductase inhibitor

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16
Q

What is the MOA of finasteride (proscar)

A

Blocks conversion of testosterone to dihydrotestosterone

17
Q

What is low dose finasteride used to treat

A

male pattern baldness

18
Q

What are side effects of finasteride

A

impotency

19
Q

Which urinary drugs are category X

A

finasteride, ciprofloxin or other quinolones

20
Q

What is Dr. Miller’s go-to drug for cystitis

A

Trimethoprim/ Sulfa DS

21
Q

What antibiotic should not be used in pregnant or lactating women, or children

A

ciprofloxin and other quinolones

22
Q

What happens when a person takes phenazopyridine (pyridium)

A

the urine changes to a bright orange color.

23
Q

WHat effect does phenazopyridine (pyridium) have

A

It relieves the symptoms of urinary irritation, but does not treat the cause

24
Q

What is a risk of using phenazopyridine

A

it may mask worsening symptoms, thus it is only prescribed for 2 days or so

Pharm 1 (14 decks)

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