Uveitis Vol. 2 Flashcards Preview

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Flashcards in Uveitis Vol. 2 Deck (39):
1

What type of bacteria is associated with LPS endotoxin?

Gram-negative bacteria

2

What protein is responsible for most of the inflammatory effects of LPS?

Lipid A

3

What type of immune response is directed against LPS?

Innate immune response

4

What is the major cause of shock, fever, and sepsis in gram-negative infections?

LPS

5

What type of immune response is associated with Type I hypersensivity?

Anaphylactoid

6

What type of immune response is associated with Type II hypersensivity?

Cytotoxic antibodies

7

What type of immune response is associated with Type Ill hypersensivity?

Immune complex reactions

8

What type of immune response is associated with Type IV hypersensivity?

Cell-mediated

9

What type of immune response is associated with Type V hypersensivity?

Stimulatory

10

What is function of the Fe portion of antibodies?

Attachment site of effector cells

11

What are idiotopes?

Anitgenic sites on antibodies that other antibodies can bind to

12

What are idiotypes?

Antibodies to idiotopes

13

What is the most common immunoglobin found in the serum?

lgG

14

What type of antibody crosses the placenta?

IgG

15

What type of antibody is associated with mast-cell degranulation?

IgE

16

What is a classic example of antibody complex binding that activates the complement cascade by the membrane attack complex?

Hemolytic anemia of the newborn (eg. due to Rh incompalibilty)

17

What is the most commonly type of cancer associated with cancer-associated retinopathy?

Small-cell lung cancer

18

What causes cancer-associated retinopathy?

Antibody mediated cross-reaction between tumor antigens and ocular autoantigens

19

What is Goldmann-Witmer coefficient used to measure?

Ratio of intraocular localantibody production compared to serum antibody production

20

What autoantigen is associated with Wegener granulomatosis?

Proteinase-3

21

What is the function of IFN-gamma and TNF-B?

Activation of macrophages

22

What type of cells are CD8 cytotoxic T-cells especially good at killing?

Tumor cells and virus infected cells

23

What is the function of CD951igand (Fasl)?

Cell-programmed death (eg. apoptosis)

24

What is primary type of immune reaction in sympathetic ophthalmia?

Th1 delayed-hypersensitivity response

25

What autoantigens are thought to be responsible for sympathetic ophthalmia?

Retinal or uveal antigens

26

What is the most frequent opportunistic ocular infection in patients with AIDS?

CMV

27

What type of delayed hypersensitivity response is thought to play a role in allergic conjunctivitis?

Th2-mediated delayed hypersensitivity

28

Which type of immunity typically activates the classical complement pathway?

Adaptive immunity

29

Which type of immunity typically activates the alternative complement pathway?

Innate immunity

30

What are the principal complement-derived immune mediators?

Anaphylatoxins

31

What complement factor is responsible for opsonization?

C3b

32

What is the primary role of the Hageman factor-dependent pathway?

Activation of kinins

33

What enzyme is responsible for the activation of kinins?

Kallikrein

34

What enzyme converts fibrinogen to fibrin?

Thrombin

35

What enzyme is responsible for degradation of fibrin?

Plasmin

36

What is the principle source of serotonin?

Platelets

37

What two types of cells release histamine?

Mast cells and basophils

38

What is the primary function of cyclooxygenase?

Conversion of arachidonic acid to PGG2

39

What type of immune mediators are thought to play a role in cystoid macular edema associated with anterior segment surgery or trauma?

Prostaglandins