Glaucoma Vol. 1 Flashcards Preview

Complete Review Course > Glaucoma Vol. 1 > Flashcards

Flashcards in Glaucoma Vol. 1 Deck (60)
Loading flashcards...
1

Name the 3 anatomical factors that determine lOP.

1. Rate of aqueous humor production 2. Resistance to aqueous outflow 3. Level of episcleral venous pressure

2

What is preperimetric glaucoma?

Glaucomatous changes of optic disc in patients without visual field defects

3

What is the the specific site of aqueous outflow resistance generally considered to cause primary open-angle glaucoma?

Juxtacanalicular meshwork

4

What is the most common cause of non-reversible cause of blindness in blacks?

Glaucoma

5

Name 3 anatomical characteristics that may make African-Americans more susceptible to glaucoma.

1. Larger optic discs 2. More nerve fibers 3. Thinner central corneas

6

What ethnic group has the highest prevelance of PACG?

Inuit populations of the Artic

7

What gender is at higher risk for PACG?

Women

8

How does the anterior chamber change with age?

Anterior chambers decreases in depth and volume with age

9

What is the most common age associated with acute angle-closure glaucoma?

Age 55 to 65

10

What type of refractive error is at increased risk of PACG?

Hyperopia (due to decreased anterior chamber depth)

11

What protein produced by trabecular meshwork cells has bean linked to genetic studies of POAG?

Myocilin (TIGR protein)

12

What gene was the first to be associated with POAG?

GLC1A

13

What protein is produced by the GLC1A gene?

TIGR/MYOC

14

What type of glaucoma has been associated with GLC1B and GLC1E gene?

Low-tension glaucoma

15

On what chromosome is GLC1A gene found?

Chromosome 11

16

On what chromosome is GLC1C gene found?

Chromosome 3

17

What structure creates the aqueous humor?

Ciliary processes

18

What chromosome has been associated with nanopthalmos associated glaucoma?

Chromosome 11

19

What specific cells of the ciliary processes are the actual site of aqueous humor production?

Inner, nonpigmented epithelial cells

20

What type of transport mechanism accounts for the majority of aqeuous humor production?

Active transport

21

What is the average production rate of aqueous humor?

2.0 to 2.5 uL/min

22

What is the most common method used to measure rate of aqueous formation?

Fluorophotometry

23

What gene is associated with aniridia and glaucoma?

PAX-6 gene

24

What is the average rate of outflow of aqueous humor?

0.2 to 0.3 uL/min/mmHg

25

How are aqueous humor production and outflow change with age?

Both are decreased

26

What artery supplies the ciliary processes?

Major arterial circle of the iris

27

What is the average turnover rate of aqueous humor?

Approx. 1% per minute

28

Nama the 3 layers of the trabecular meshwork.

1. Uveal 2. Corneoscleral 3. Juxtacanalicular

29

Name 3 classes of glaucoma drugs that cause decreased aqueous formation.

1. alpha-2 agonists 2. Beta-blockers 3. Carbonic anhyrdase inhibitors (Think "ABC")

30

What is the average diameter of Schlemm's canal?

370 um