Pathology Volume 3 Flashcards Preview

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Flashcards in Pathology Volume 3 Deck (34):
1

What type of collagen is associated with Descemet's membrane?

Type IV collagen

2

What is the most common inheritance pattern of CHED?

Autosomal recessive

3

What is the most common ocular association of sclerocornea?

Cornea planus

4

Of the classic corneal stromal dystrophies, which is autosomal recessive?

Macular dystrophy

5

What causes corneal whorls?

Deposition of lysosomal deposits within the basal layer of the epithelium

6

What chromosome is associated with macular dystrophy?

16q

7

What chromosome is associated with granular. Lattice and Avellino dystrophy?

5q

8

What causes corneal guttae?

Focal thickening of Descemet's membrane

9

What condition is associated with PITX2 gene?

Axenfeld-Rieger syndrome

10

What is Axenfeld anomaly?

Posterior embryotoxon and iris adhesions to the cornea

11

What is Axenfeld syndrome?

Axenfeld anomaly plus glaucoma

12

What is Rieger anomaly?

Axenfeld anomaly plus iris atrophy

13

What is Rieger syndrome?

Rieger anomaly plus dental and skeletal abnormalities

14

What is thought to cause pigment dispersion syndrome?

Rubbing of the iris pigment epithelium by lens zonules

15

Name 3 systemic associations of exfoliation syndrome.

1. Hypertension 2. Stroke 3. Myocardial infarction

16

What does angle recession represent histologically?

Tear in the ciliary body between the longitudinal and circular muscles

17

Name 3 ocular complications of nanopthalmos.

1. Hyperopia 2. Glaucoma 3.Uveal effusion syndrome

18

Name the 3 layers of the sclera.

1. Episcleral 2. Stroma 3. Lamina fusca

19

What condition is associated with proliferation of spindle calls in a storiform pattern?

Fibrous histiocytoma

20

How is the sclera altered in nanopthalmos?

Sclera is abnormally thick in nanopthalmos

21

What is the most common location of senile calcific plaques?

Anterior to the lateral and medial rectus muscles

22

What structures represent the tertiary vitreous?

Zonular fibers

23

What does Bergmeister papilla represent?

Remnant of the posterior portion of the hyaloid artery

24

What is the most common location of Mittendorf dot?

Inferonasal posterior capsule

25

What disorder is associated with "candlewax drippings" of the retinal vasculature?

Sarcoidosis

26

In what layer of the retina do cystic spaces occur in typical peripheral cystoid degeneration?

Outer plexiform layer

27

In what layer of the retina do cystic spaces occur in reticular peripheral cystoid degeneration?

Nerve fiber layer

28

What protein is associated with amyloid deposits of the vitreous?

Transthyretin

29

What condition is associated with amyloid deposits of the vitreous?

Familial amyloid polyneuropathy

30

What is the most common location of degenerative retinoschisis?

Inferotemporal

31

Where does reticular peripheral cystoid degeneration occur?

Posterior to areas of typical peripheral cystoid degeneration

32

What is the most common type of degenerative retinoschisis?

Reticular degenerative retinoschisis

33

What causes the clinical appearance of cobblestone degeneration?

Adherence of the inner nuclear layer to Bruch's membrane

34

What do cytoid bodies represent?

Swollen NFL axons