Uveitis Vol. 3 Flashcards Preview

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Flashcards in Uveitis Vol. 3 Deck (32):
1

What medication has been found to diminish the onset of mild CME following surgery?

COX inhibitors (egg. by inhibition of prostaglandins)

2

By what mechanism is lOP thought be lowered in uveitis?

Release of PGE1, causing increased uvoscleral outflow as well as decreased aqueous humor production

3

What are the final products of the 5-lipoxyganasa pathway?

Leukotrienes

4

What pathway is associated with platelet-activating factors?

Remodeling pathway

5

What are chemokines?

Cytokines associated with chemotaxis

6

What cytokine is responsible for migration of Langerhans cells to the central cornea?

IL-1

7

What enzyme is responsible for the formation of hydrogen peroxide?

Superoxide dismutase

8

What is the function of Fenton and Habar-Weiss reaction?

Breakdown of hydrogen peroxide into OH- and hydroxyl free radical

9

What are the 3 class I MHC molecules?

HLA -A, -B,-C

10

What are the 3 class II MHC molecules?

HLA -DR, -DP, -DQ

11

What percentage of patients with acute anterior uveitis express the HLA-B27 haplotype?

Approx. 50%

12

What HLA is associated with acute anterior uveitis?

HLA-B27

13

What HLA is associated with Reiter syndrome?

HLA-B27

14

What HLA is associated with Adamantiades-Behcet syndrome?

HLA-B51

15

What HLA is associated with Birdshot chorioretinitis?

HLA-A29

16

What HLA is associated with sympathetic ophthalmia?

HLA-DR4

17

What HLA is associated with VKH syndrome?

HLA-DR4

18

What HLA is associated with sarcoidosis?

HLA-B8

19

What HLA is associated with multiple sclerosis?

HLA-B7

20

What HL.A is associated with ocular histoplasmosis syndrome (OHS)?

HLA-B7

21

What HL.A is associated with retinal vasculitis?

HLA-B44

22

What is the mechanism of action of corticosteroids?

Bind intracellular receptors that translocate into the nucleus and altars DNA transcription into mRNA

23

What is the mechanism of action of alefacept?

CD2 receptor inhibitor (e.g. T-cells)

24

What is the mechanism of action of efalizumab?

CD11a receptor inhibitor (e.g. T-cells)

25

What is the mechanism of action of anakinra?

IL-1 receptor inhibitor (e.g. macrophages)

26

What is the mechanism of action of etanercept?

TNF-alpha

27

What is the mechanism of action of infliximab?

TNF-alpha

28

What is the mechanism of action of adalimumab?

TNF-alpha

29

What is the mechanism of action of rituximab?

CD20 inhibitor (e.g. B-cells)

30

What is the mechanism of action of daclizumab?

CD25 inhibitor (e.g. activated T-cells)

31

What glycoprotein is found on the surface of all B-calls?

CD20

32

What glycoprotein is found on the surface of activated T-cells?

CD25