Viral Structure, Replication and Pathogensis Flashcards Preview

CMBM exam 3 > Viral Structure, Replication and Pathogensis > Flashcards

Flashcards in Viral Structure, Replication and Pathogensis Deck (65)
Loading flashcards...
1

What are the classifications of viruses?

Polio
Rota
Human papillo
Adeno
Semliki
Influenza
Paramyxo
Smallpox

2

What is virology?

Scientific study of viruses and disease they cause

3

What is a virus?

Infective agent typically consisting of a of a nucleic acid in a a protein coat
Obligate intracellular parasite that depends on the host for reproduction

4

How are viruses similar to living organisms?

Proteins and glycoproteins
Nucleic acid

5

How are viruses different from living organism?

No polysaccharides, small molecules or ions
If they are lipid they are only enveloped
No ribosomes

6

Do antibiotics work against viruses?

No

7

Does a virus contain DNA and RNA?

No they can only have DNA or RNA, never both

8

What are possible structures for DNA viruses?

Single or double strand
Linear or circular
Open or closed
Continuous or nicked

9

What are some possible structure for RNA viruses?

Single or double strand
Linear
Possible segmentation
Single strand may be plus or minus sense

10

What are the steps to name a virus?

1. Structure: size morphology and nucleic acid
2. Biochemical characteristics: structure and mode of replication
3. Disease
4. Means of transmission:
5. Cell, tissue or organ
6. Host cell range

11

What a virion?

Structurally complete infective virus particle

12

What is a capsid and what are capsomeres?

A protein shell that encloses the nucleic acid
Capsomeres are units on the surface in clusters

13

What is a nucleocapsid?

Capsid along with the inside nucleic acid

14

What is the tegument of a virus?

Proteinaceous material between envelope and capsid

15

If a virus is said to have an icosahedral shape, what does it look like?

Rigid and uniform structure
ex. Multiside hexagon

16

If a virus is said to have a helical shape, what does it look like?

Swirly squiggly

17

A naked virus...

Protects viral genes from inactivation by adverse environments
Packaged, protect and deliver genome
Mediate attachment (VAP)
Release by cell lysis

18

An enveloped virus...

Has a lipid bilayer with embed proteins
More susceptible to chemical agents
Determines host cell specificity and penetration
Facilitates attachment
Released by budding

19

A virus is icosahedral naked. What types of genome does it have?

dsDNA, ssDNA, dsRNA, ssRNA

20

A virus with an icosahedral shape and is enveloped has what types of genome?

dsDNA, dsRNA, ssRNA

21

A virus has a helical shape and is naked. What are its genomes?

dsDNA, ssDNA, ssRNA

22

An enveloped helical virus is found. What genome will it have?

ssRNA

23

What are the 2 types of exceptions to viral symmetry?

Complex viruses: poxvirus and bacteriophages

24

What is tropism?

Factors that affect host range

25

What are some factors that allow viruses to enter cells?

Can use more than one receptor or many viruses use the same receptor

26

What are the most common routes of entry for a virus?

Blood and bodily fluids
Insect bites
Respiratory
GI
Direct contact

27

What are some viruses that enter through blood or fluid?

CMV, EBV, HBV, HCV, HIV

28

If an insect bites you, what viruses could it transmit?

Dengue, EEEV, WEEV, West Nile

29

Oh no! You touched a surface covered in viruses! What could viruses could you get?

HSV, smallpox, VZV

30

Viruses that can be inhaled are:

Small droplets: influenza, measles, smallpox, VZV
Large droplets: adenovirus, parainfluensa, parvovirus, smallpox
Direct to secretions: RSV, rhinovirus