Virology I Flashcards
(44 cards)
viral structure
capsid - icosahedral or helical
enveloped or non-enveloped
recombination
exchange genes between 2 chromosomes
-crossing over within regions of significant base homology
reassortment
virus exchange genetic material
ex. H1N1 influenza A
complementation
1 of 2 viruses infecting cell mutation results in nonfunctional protein
making functional protein that serves both viruses
Hep B and Hep D
Hep D requires presence of replicating hep B virus
-provides HBsAg - envelope protein for Hep D
ex. of complementation
phenotypic mixing
simultaneous infection of cell with 2 viruses
form hybrid virus
- virus A with surface protein virus B
- type B coat - determine infectivity
- progeny from this infection - has virus A coat again
live attenuated vaccines
smallpox yellow fever rotavirus chickenopx sabin polio virus MMR influenza (intranasal)
“mMR. I. Sabin, the Small Yellow Rotating Chicken.”
dangerous to give to immunocompromised pts
Mr. I Sabin, the Small Yellow Rotating Chicken
MMR influenza (intranasal) Sabin polio virus smallpox yellow fever rotavirus chickenpox
live attenuated vaccines
killed viral vaccine
rabies, influenza (injected)
salk polio
HAV
HBV vaccine
HBsAg
HPV vaccine
subunit
-type 6, 11, 11, 16, 18
parvovirus
only DNA virus single strand
” part of a virus”
reoviridae
only RNA virus double strand
“repeat-o-virus”
most DNA virus
dsDNA
most RNA virsu
ssRNA
“I went to a retro toga party where I drank flavored corona and ate hippy california pickles.”
positive strand RNA viruses
retrovirus togavirus flavivirus coronavirus hepevirus calicivirus picornavirus
positive strand ssRNA
equal to mRNA
-no need for polymerase
require polymerase
negative strand ssRNA and dsRNA
DNA virus replication
in nucleus
except poxvirus
RNA virus replication
in cytoplasm
except influenza and retrovirus
non-enveloped viruses
give PAPP smears and CPR to a naked hippy
naked - non-enveloped
DNA - PAPP - papillomavirus, adenovirus, parvovirus, polyomavirus
RNA - CPR hippy - calcivirus, picornavirus, reovirus, hepevirus
herpes virus envelope
gets envelope from nuclear membrane
enveloped virus get envelope
from plasma membrane
exception - herpes - gets from nuclear membrane
HHAPPPPy
DNA viruses
hepadna herpes adeno pox parvo papilloma polyoma
