Virology III

Question 1

influenza virus

Answer 1

orthomyxoviruses
enveloped
negative ssRNA
8 segment genome

Question 2

hemagglutinin

Answer 2

in influenza virus - promote viral entry

Question 3

neuraminidase

Answer 3

in influenza virus - promote progeny virion release

Question 4

live attenuated vaccine

Answer 4

replicat in nose - not lung

Question 5

genetic shift

Answer 5

causes pandemics

dangerous

Question 6

genetic drift

Answer 6

causes epidemics

less dangerous

Question 7

sudden shift more deadly than gradual drift

Answer 7

genetic shift worse than genetic drift

Question 8

blueberry muffin baby

Answer 8

congenital rubella infection

-extramedullary hematopoiesis

Question 9

rubella virus

Answer 9

togavirus

german 3 day measles

Question 10

fine clonfluent macule rash that starts on face and spread centrifugally to involve trunk and extremities

Answer 10

rubella rash

Question 11

paramyxovirus

Answer 11

disease in children

all have surface F protein - fusion to respiratory epithelium

Question 12

laivizumab

Answer 12

monoclonal Ab against F protein - prevent pnueumonia caused by RSV in premature infants

Question 13

croup

Answer 13

parainfluenza - is a paramyxovirus

seal like bark and inspiratory stridor

steeple sign on Xray

Question 14

measles virus

Answer 14

paramyxovirus

Question 15

prodrome fever with cough, coryza, conjunctivitis, eventual koplik spots, maculopapular rash starts at head/neck and spreads down

Answer 15

measles

Question 16

koplik spots

Answer 16

measles

red spot with blue white center

Question 17

coryza

Answer 17

rhinitis

Question 18

reduce measles mortality

Answer 18

vit A supplements

Question 19

mumps

Answer 19

paramyxovirus

covered in MMR vaccine

Question 20

parotitis, orchitis, aseptic meningitis

Answer 20

mumps

risk of sterility

Question 21

bullet shaped virus

Answer 21

rabies virus

Question 22

negri bodies

Answer 22

rabies virus

cytoplasmic inclusions

Question 23

rabies virus infection

Answer 23

long incubation before sx

• travel to CNS - migrating retrograde up nerve axon
• bind ACh receptor

bat, raccoon, skunk bite

fever, malaise > agitation, photophobia, hydrophobia, hypersalivation > paralysis, coma > death

Question 24

ebola virus

Answer 24

filovirus

target endothelial cells, phagocytes, hepatocytes

flu-like sx, diarrhea, vomiting, fever, myalgia, DIC, diffuse hemorrhage

no tx - supportive care

transmission - direct contact body fluid

Question 25

hepatitis A virus

Answer 25

RNA picornavirus fecal oral route

Question 26

hepatitis B virus

Answer 26

DNA hepadnavirus sexual transmission DNA polymerase with both RNA and DNA activity -

Question 27

hepatitis C virus

Answer 27

RNA flavivirus blood transmission

Question 28

hepatitis D virus

Answer 28

RNA delta virus require hep B

Question 29

hepatitis E virus

Answer 29

RNA hepevirus

Question 30

councilman bodies

Answer 30

eosinophilic apoptotic globules with hepatitis and elevated ALT and AST

Question 31

anti-HAV IgM

Answer 31

acute hepatitis A

Question 32

anti-HAV IgG

Answer 32

prior hep A infection or vaccination | -protect against reinfection

Question 33

HBsAg

Answer 33

surface Ag hepatitis B indicates infection

Question 34

anti-HBs

Answer 34

antibody to HBsAg | -indicate immunity to hep B

Question 35

HBcAg

Answer 35

core hepatitis B antigen

Question 36

anti-HBc

Answer 36

IgM - acute recent infection | IgG - prior exposure - chronic infection

Question 37

window period

Answer 37

IgM anti-HBc may be sole positive marker

Question 38

viral hepatitis

Answer 38

ALT > AST

Question 39

alcoholic hepatitis

Answer 39

AST > ALT

Question 40

HBeAg

Answer 40

indicate active viral replication | -high transmission

Question 41

anti-HBeAg

Answer 41

low transmission

Question 42

indicate hepatitis B infection

Answer 42

HBsAg -decreased in window period when recovered and immunized - anti-HBsAg

Question 43

high vs. low infective hepatitis B

Answer 43

HBeAg - high | anti-HBeAg - low