Virology IV

Question 1

3 genes of HIV

Answer 1

structural

env - gp120 and gp41
gag - p24
pol - reverse transcriptase, aspartate protease, integrase

Question 2

HIV reverse transcriptase

Answer 2

synthesize dsDNA from genomic RNA

dsDNA - integrated to host genome

Question 3

HIV binding

Answer 3

gp120 - attachment to CD4+ cells

gp41 - transmembrane - fusion and entry to cell

Question 4

capsid protein HIV

Answer 4

p24

Question 5

coreceptor HIV binding

Answer 5

binds to CD4 - needs coreceptor

macros - CCR5 - early infection
T cells - CXCR4 - late infection

Question 6

homozygous CCR5 mutation

Answer 6

immune HIV

heterozygote - slower course

Question 7

diagnosis of HIV

Answer 7

ELISA - rule out test

western blot - rule in test

Question 8

diagnosis of AIDS

Answer 8

CD4 less than 200

Question 9

anti-gp120

Answer 9

cross placenta

Question 10

infection in HIV positive - CD4 less than 500

Answer 10

candida 
EBV
bartonella hencellae
HHV-8
cryptosporidium
HPV

Question 11

HIV candida

Answer 11

CD4 less than 500

Question 12

HIV EBV

Answer 12

CD4 less than 500

Question 13

HIV bartonella henselae

Answer 13

CD4 less than 500

Question 14

HIV HHV8

Answer 14

CD4 less than 500

Question 15

HIV cryptosporidium

Answer 15

CD4 less than 500

Question 16

HIV HPV

Answer 16

CD4 less than 500

Question 17

HIV CD4 less than 200

Answer 17

toxoplasma gondii
HIV
JC virus
pneumocystic jirovecii

Question 18

HIV toxoplasma gondii

Answer 18

CD4 less than 200

Question 19

HIV HIV infection

Answer 19

CD4 less than 200

Question 20

HIV JC virus

Answer 20

CD4 less than 200

Question 21

HIV pneumocystic jirovecii

Answer 21

CD4 less than 200

Question 22

HIV patient CD4 less than 100

Answer 22

aspergillus
cryptococcus neoformans
candida albicans
CMV
EBV
histoplasma capsulatum
mycobacterium avium intracellulare

Question 23

HIV aspergillus

Answer 23

CD4 less than 100

Question 24

HIV cryptococcus neoformans

Answer 24

CD4 less than 100

Question 25

HIV candida albicans

Answer 25

CD4 less than 100

Question 26

HIV CMV

Answer 26

CD4 less than 100

Question 27

HIV EBV

Answer 27

CD4 less than 100

Question 28

HIV histoplasma capsulatum

Answer 28

CD4less than 100

Question 29

HIV myobacterium avium intracellulare

Answer 29

CD4 less than 100

Question 30

prion disease

Answer 30

alpha-helical protein - to beta-pleated form PrP-C to PrP - SC resistant to sterilizing procedures - including autoclave

Question 31

spongiform encephalopathy

Answer 31

prio disease

Question 32

creutzfeldt jakob disease

Answer 32

rapid progressive dementia typically sporadic prion disease

Question 33

bovine spongiform encephalitis

Answer 33

prion disease aka mad cow disease

Question 34

kuru

Answer 34

acquired prion disease cannibals - who eat brains