Virology12 Flashcards

(49 cards)

1
Q

T or F

Immunosuppresion caused by HIv has the same influence as that of organ transplant

A

False

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2
Q

Primary acute HIV syndrome is much like that of—— so we call it —–
Some of it’s symptoms are :
1-
2-

A

EBV
Mononucleosis like syndrome
Hepatosplenomegaly
Pruritic Rash

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3
Q

T orF

Signs of HIV acute syndrome are clear ,specific and we can tell that this patient has HIv from this stage

A

False

Most patiets enter the clinical latency without anyone knowing

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4
Q

T or F

In HIv we have viral latency

A

False

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5
Q

T or F
If the patient came with recurrent diarrhea and night sweats, candidisis
This raise the suspicion that he might have HIV

A

Truee

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6
Q

T or F

In acute HIV syndrome we have immunosuppresion

A

False

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7
Q

T or F

HIV acute syndrom can’t go asymptomatic

A

False

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8
Q

People who have covid and living with HIV but on HAART have (severe/normal)—– infection. They might have (longer/shorter)—— covid symptoms.
The most cases of HIV are in —— where we have ——— and——,that was the problem regarding ppl livin with HIV.

A
Normal
Longer
Africa
Low vaccination
Overwhelming of healthcare sys
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9
Q

People living with HIV are like COVID patients are prone to —– and —– on the long term

A

Cardiovascular disease

Diabetes

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10
Q

T or F

During clinical latency the patient is not infectious

A

Akid infetious le3en den l manta2a

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11
Q

Oral hairy leukoplakia as a —— is caused by —– in immunosuppresed patients or even in ——-

A

Constitutional symptom
EBV
Early acute HIV syndrome

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12
Q

——- is caused by HHV8 in immunosupp ppl, which is ——

A

Kaposi sarcoma

Connective tissue malignant cancer

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13
Q

T or F

Kaposi sarcoma is a blanching macculopapular rash

A

False

Non blanching

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14
Q

T or F

Most of kaposi sarcomas are unnoticed

A

True (taht usbaa ejru)
We should always examine skin and oral cavity
Pleaseeeeee shufun

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15
Q

Data showed we have (male/female) —— predisposition to kaposiii

A

Male

Male:female (17:1)

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16
Q
AIDS defining illness
1-
2-
3-
4-

+1-
2-
3-

A

1-CD4<200
2-pulmonary tuberculosis
3- recurrent pneumonia
4-invasive cervical cancer

Kaposi
Pneumocystis carini pneumonia (b america is more prevalent than TB so by3tbruwa as aids defining illness)
Esophageal candidasis

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17
Q

TB infection increases by —– fold in HIV patients, we can screen by—- and —–

A

20 fold
PPD (>5)
Chest x ray looking for tubercles and not granulomas (laanu l granuloma kter zghar) (tubercles hene majmu3t granulomas)

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18
Q

Coccidioides immitis aka —— caused by —— , causes —– fever but in immunosupp ppl it will cause —– or —— when the CD4 drops below—–
Mainly in ——(country)

A
Coccidioidomycosis
Mycelium of fungu
Valley
Very severe pneumonia
Meningitis
250
USA
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19
Q

Pneumocystis carini pneumoniae aka —–is a —– causes —–,—– and ——
However in immunosuppressed patients it causes ——- that appear on CT scan like —–, when the CD4 drops to ——
Prophylaxis:

A
Jirovecii
Yeast fungus
Fever-dyspnea-cough
Ground glass pattern pneumonia
CoViD
Less than 200
Bactrim
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20
Q

T or F

Fungal pneumonia or recurrent bacterial pneumoni in a healthy looking patient is suspicious and i should do HIv test

21
Q

T or F

Recurrent Bacterial pneumonia appears only when CD4 count drops below 200

A

False

May appear on 400-500

22
Q

Main bacteria that causes recurrent pneumonia :
1-
2-

A

Hemophilus influenzae

Strep pneumonia

23
Q

Candida albicans causes —— in immunocompetent patients while in immunosuppressed ppl it causes mainly —— and ——, when the CD4 count drops below—–

A
Superficial friable white lesions on mucosa only (mesh mtl l oral leukoplakia ma beruhu)
Esophageal candida (can be from 
omeprazole)
And cutaneous candida
200
24
Q

Histoplasma capsulatum are —— fungus live in —– and it can be —–, feathers of the bird and GI of —-, in immunosuppresed patients it causes—– which can be confusing with —– also can cause ——- when the CD4 count drops below—–

A
Dimorphic
Soil
Airborne
Bats
Granulomatous pulmonary disease
TB
Dissemenated histoplasmosis rash
150
25
Cryptococcus neoformans is aquired from ------, in immunosuppressed it causes ----- when the CD4 count drops below -----
Pidgeon droplets CNS disease (encephalitis or meningitis) 100
26
Cryptosporidium parvum and ----- causes ------ in HIV patients when the CD4 count drops below -----
Isospora belli Chronic diarrhea (feha tkun mn giardia aw salmonellaa) 100
27
The diarrhea is considered persistent after ----- and chronic after ------
2 -4 weeks | 1 month
28
HSV causes ------- in HIv patients but will be ------- that will be (painless/painful)------also on the anal level it will develop to------ Also may cause----- and ------ When the CD4 count drops below-----
``` ulcers Severe and chronic Very painfulll HSV proctitis Esophagitis Eczema herpeticum 100 ```
29
Ulcers are considered chronic after ------
Few weeks (1-2 months)
30
JC virus in normal individual causes ----- while in HIV patients it causes ------- Progressive because it appears as -----,----- and ------ those will lead to ----- when the CD4 count drops below----- Tx:-----
``` Asymptomatic to prodromal Prog multifocal leukoencephalopathy Vision problems , speech and personality shifts Prog weakness 100 HAART ```
31
JC virus is transmitted thru----- with latency in ----- and -----, reactivation happens when we have ------ Transported thru the BBB inside----
Inhalation Kidney and bone marrow Immunosuppresion B cells
32
``` CMV causes ------- under --- CD4 count and can cause -----, on the brain level it causes ---- And ------ in GIT When the CD4 count drops below---- Tx: Also we should ---- ```
``` Retinitis 1 Blindness Encephalitis Colitis 50 Acyclovir(?) with HAART Screen ```
33
If we wanna diagnose the disease with CMV we should ask for ------ or -----, if below 50 and i wanna know if he has CMV i make ------
PCR from stool specimen or CSF | Serology
34
T or F | Every organ can be involved in CMv
True
35
CMV is a ----- for HIV
Co-infection
36
Mycobacterium avium complex below cd4---- causes ------ and ----
50 Anemia Dissemination RES
37
T or F | Mycobacterium avium is atypical and causes the disease alone
False | Multiple microorganisms
38
Toxoplasma gondi causes ------ under cd4 count of ------ | We should screen at ----
Space occupying lesions/neuroligical manefistations 50 Any CD4 count like in TB
39
T or F | Mycobacterium avium is the the most common cause of neurological manefistation with a patient livin with AIDS.
False | Toxoplasmosis
40
HPV is the ----- STI in most people it's ----- and------- Genome: Envelope: Cutaneous HPV is (malignant/not)----- but in cervix or -----it's ----- and it causes -----
``` Most common in the whole world Dormant Oncogenic DsDNA circular Naked Not Penis Malignant Dysplasia ```
41
Screening for HPV: Vaccines for HPV: Vaccines is recommended for ------
Pap smear Gardasil Cervarix Women and men
42
List some microorganisms when present we will be more exposed to HIV because of broken skin: (co-infections) or co-factors
``` Hemophilus ducreyi Treponema pallidum HCV EBV CMV HSV HBV ```
43
``` Pediatric AIDS Clinical latency : Death (without HAARt): Oral candidiasis is (less/more) ------ severe than adults, with ------ and ------ ------ because of bacteria with ------ ```
``` 2 4 More Encephalopathy-pneumonitis(inflamation of conn tissue)/ pneumonia Sepsis Wasting ```
44
Aids causes ------- aka----- and -----on CNS on the long run by destruction of -----, also------ on PNS
Dementia aka aids dementia complex Aseptic meningitis Neurons Peripheral neurophathy (bebatl yhes b ejre)
45
``` AIDS dementia complex characterisation: 1- 2- 3- 4- 5- ```
``` Memory loss Concentration Apathy Psychomoto problem Behaviour (awkward) ```
46
Without HAART, after aids dementia complex the patient will die in ----- Neurological consequences of HIV along with cancer caused by HIv will (complete/stop)------ with treatment
6 m | Complete regardless of treatment
47
``` Ppl livin with HIV and taking HAARt have higher risk of : 1- 2- 3- 4- ```
``` Cardiovascular disease Dementia Diabetes Cancer (CNS lymphoma and burkitts) 2C 2D ```
48
``` HAART: Current problem is because of: U=U: Effect of uncompliance in therapy: 3 fam of drugs: Reason of triple therapy: Prep: Role of prep: Composition of prep: Paradoxycal effect of prep: ```
Highly active antiretroviral therapy Stigma Untrasmissible if undetected viral load even if it's unprotected sex Resistance 2 nucleoside reverse transcriptase inhibitors + 1 nonnucleoside or integrase inhibitor If one have resistance there are other 2 working Pre-exposure prophylaxis: HIV will not transmitted by having sex with a HIV+ Prep=treatment -1 less condoms usage fa balash ynta2al eshya tenye (ducreyi,syphilis)
49
T or F | Universally the highest HIV percentage is amongst homosexuals
False | Laanu b africa (2/3 of cases) are among heterosexuals