Virology8

Question 1

EBV
Genome length:
Host cell:
Causes---------
Receptor:
Genome type:
Reactivation will lead to:

Answer 1

1-172 kb 100 genes (70 proteins)
2-B lymphocytes (can transmitt it to other by circulation) in salivary glands
3-Acute infectious mononucleosis (increasing monocytes, glandular fever)
4-C3b (complement receptor)
DNA
Lysis of cell

Question 2

T or F

EBV is not oncogenic

Answer 2

False

Question 3

Types of antigens presented by EBV

Answer 3

Latent phase:
1-EBNA1 maintain episomes in circular shape in nucleas
2-LMP1:activated GF receptor

Early antigens: NSPs onset of replication (functional antigens)

Late: VIral capsid-envelope antigens

Question 4

Interpret:
VCA IgM +  VCA IgG +  EBNA IgG- --------
VCA IgM - VCA IgG + EBNA IgG + -------
VCA IgM + VCA IgG + EBNA IgG + ------
Oral viral load remain more than blood-----

Answer 4

Acute infection
Past infection
Reactivation
Capable of more shedding

Question 5

Persistence of the virus is caused by ——–

In germinal B cells because of latency this leads to ——

Answer 5

Change in latent antigens

Hodgkin lymphoma and burkitts

Question 6

Two oncogenic forms of EBV infection after latency are:

Answer 6

Hodgkin’s lymphoma
Burkitt’s lymphoma
Associated with nasopharyngeal carcinoma

Question 7

EBV causes polyclonal stimulation of ——-

Mononucleosis:

Answer 7

B cells

Mononucleosis is the polyclonal stimulation

Question 8

Monospot test(sheep blood) is used to detect presence of —— which indicates if it’s positive the presence of —— mainly or ——

Answer 8

Heterophil antibody
EBV ( 80% of cases)
CMV (20% of cases)

Question 9

Infectious mononucleosis

IP:
Symptoms:
Severity:
Residual symptoms: 
Transmission:
High risk
Adult seroconversion:

Answer 9

Ip: 1-2 months
Symptoms: fever- sore throat(white patches) and tonsils may block airways- LN-splenomegaly(rapture)-hepatomegaly(hepatitis and elevated LFT) 
Self-limited but doesn't disappear quickly.
Not children (bekun milder la age of 5)
Bkhaf mn strepA
Chronic Fatigue syndrome and myalgia
Through saliva and contact (kissing)
90% by age of 40-50

Question 10

If an EBV infected patient was given penicillin this will lead to———, this will (remain/disappear) —— after stopping this med

Answer 10

Pruritic maculopapular rash

Disappear

Question 11

How can we detect EBV by CBC?

Answer 11

Thrombocytopenia

Neutropenia

Question 12

T or F

T lymphocytes are not affected by EBV

Answer 12

False

They have atypical shape

Question 13

Burkitt’s lymphoma is caused by EBV and —— which is a co-factor, this will lead to ——- and over expression of —— this oncogene will lead to burkitts lympho

Answer 13

Malaria
Chromosome translocation
C-myc

Question 14

The most painful cancer caused by EBV is ——-

Answer 14

Jaw sarcoma

Question 15

T or F

White people are more likely to produce infectious mono

Answer 15

True

Question 16

T or F

Black people are more likely to make tumors

Answer 16

True because of latency

Question 17

Nasooharyngeal carcinoma is more common in ——- it affects —- and —–

Answer 17

Southern eastern asian males (chinese)
Pharynx
Eustachian tube

Question 18

T or F

EBV causes nasooharyngeal carcinoma

Answer 18

False
It’s associated with it
I can find by pcr EBV DNA

Question 19

Oral hairy leukoplakia is caused by —– mainly in ——-,immunosuppressed patients may suffer from —— characterized by hepatic necrosis and ——

Answer 19

EBV
Immunosuppressed patients (AIDS)
Lymphoproliferative disease
Pancytopenia

Question 20

T or F

CMV can infect every organ

Answer 20

True
Breast milk
Shedd in stool

Question 21

Mode of transmition of CMV

Answer 21

Breast milk
Sexual contact
Fecal oral

Question 22

Site of latency:

Answer 22

Kidney
Spleen, wen ma ken
Myeloid cells of bone marrow

Question 23

After —— we should do the CMV antibodies test

Answer 23

Transplantation ( eg. Kidney)

Question 24

Shape of CMV on microscope:

Answer 24

Owl eye

Question 25

T or F | CMV is a slow replicator

Answer 25

True | Unlike Like HSV which is fast

Question 26

CMV in immunosuppresed patients can cause:

Answer 26

Colitis Pneumonitis Chorioretinitis (T4 less than 10) Hepatitis

Question 27

T or F | EBV can't cause hepatitis

Answer 27

False

Question 28

Congenital CMV:

Answer 28

Petechiae(non blanching)-jaundice-hepatosplenomegaly Hearing loss Chorioretinitis Strabismus (حول( whde mn l occular muscles mesh shaghale)

Question 29

Organisms Causing microcephaly:

Answer 29

``` Toxoplasma Others (syphilis and zeka) Rubella CMV HSV ```

Question 30

Why do they call infetious mono glandular fever?

Answer 30

Because it causes the enlagement of the RE system (liver-spleen-LN)

Question 31

Africans tumors are 90% positive for ------

Answer 31

EBV

Question 32

cmv symptoms during pregnancy

Answer 32

Vasculitis (uterus or placenta ) that lead to hypoperfusion Microcephaly Polyhydramnios (excess amniotic fluid) Olygoamnios ( less amniotic fluid)

Question 33

T or F | Jaundice is common in adult EBV infection than congenital one caused by CMV

Answer 33

False | Reversed

Question 34

Pregnant woman should't come in contact with ------ and ------- because CMv could be transmitted by saliva

Answer 34

Toddlers | Young babies

Question 35

Echolalia habet

Question 36

T or F | CMV is a co-factor for HIV infection

Answer 36

``` True Increased T4 proliferation Direct transactivator of latent HIV Inhibit apoptosis of HIV infected cells Inflammation and altered trafficking Induction of inhibitory pathways ```

Question 37

``` HHV 6 and 7 cause rash called------aka---starts with ------ last to ------ and the infant is (active/no)---- Also may cause : Self limited or chronic: Latency: Associated with : ```

Answer 37

``` Exanthem subitum aka Rosiola infantum High fever (40 ) 3-5 days (looks active) Uvulopalatal (papules)(2/3 of patients) Then macculopapular rash after the fever is gone (trunk then neck face and extremity) (rash from 1 to 2 days) Malaise Irritability Conjunctivitis Anorexia Self limited Have latency Multiple sclerosis and alzeheimers or encephalitis (neurotropic) ```

Question 38

Kaposi sarcoma

Answer 38

Caused by HHV8 People livin with AIDS Appear anywhere on skin Violet to black lesions