Virology3 Flashcards by Mahdi Akoush

Paramyxovirus

Genome:
Envelope:
Shape:
Trans:

Ss RNA negative sense
Enveloped
Helical NC
RT

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Mumps and measles ard transmitted —– although they cause —— aka —–

RT
Dissemenated disease
Systemic viruses

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T or F

H and N proteins in paramyxo are of great importance

False

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T or F

Paramyxo have matrix

True (M protein)

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Fate of -ve strand RNA on paramyxo viruses

-make the +ve strand
1- will make mRNA that will make proteins of the virus
2-remain as template to make the viral -ve RNA

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T or F

Nipah virus is paramyxovirus

True

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T or F

Parainfluenza can’t infect adults

False it can

But most diseases are in children

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If an immunocompetent person infected with parainfluenza this will lead to ----- disease like ----- (can/can't)----- cause viremia, can dissemenate to the larynx causing :
1-
2-
3-
4-

Mild - like common cold
Can't cause viremia
1-Laryngotracheobronchitis = croup
2-pneumonia 
3-bronchiolitis
4- otitis media

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Stridor:

الشهقة

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Standard care for croup patients

Supportive care
Corticosteroids
Oxygen therapy
Epinephrine by nebulizer to open the vocal cords

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RSV is the most common cause of ——– in infants and young children

Lower respiratory tract

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RSV replicates in —– and spread too —— and may cause —– (more/less) ——common than parainfluenza in severity

Nasopharynx
Respiratory tract (bronchiolitis and pneumonia)
More

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Serious period is between —- of age where after the latter he has no risk of detrimental disease

6 weeks and 6 months

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T or F

We should give the neonates a medication without knowing the cause when fever occurs because it’s very dangerous

False
We should know if it’s UTI RT or CNS
Because fever in such young age is alarming

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Adults usually get better after —– of infection with RSV while children takes ——-

2 days

2 weeks

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—– infected by RSV by age 1

- —– by age 2

70-%

100%

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T or F

RSV is cytopathic

Yes because it form syncytia (giant cell)

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F spike protein is a —– protein found in —— virus

Fusion

RSV

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T or F

RSV is not bimodal

False it is

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T or F

RSV is not very common in a nosocomial setting

False

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Tx for RSV

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Ribavirin (children mainly)

Mode of trans of RSV

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Large droplets

Contact

Is there a vaccine for RSV?

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Nah

If there is it should be for the mother so that she can give her child passive immunity

Mumps (can/can’t) —– cause systemic diseases eventually lead too ——-&——, —— of the infections are asymptomatic

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Can
Meningitis(more common in males) and orchitis
35%

T or F | The child infected with mumps can transmitt the virus even before the prodromal phase

True

T or F | Humans ain't the only reservoir for mumps

False

Parotitis a characteristic of ------ and it's (obligatory/non)------ step of this virus, the virus (can/can't)----- cause viremia

Mumps virus Non obligatory Can

Mumps is viscerotropic and can cause ------- and------ then we can detect it in ------- aka ----- IP:

``` Pancreatitis Kidneys Urine after 2 weeks of symptoms Viuria (can detect it after 2 weeks of symptoms) 2 to 4 weeks ```

Mumps is more common in (males/females)------- which causes ----- more than ------

Males Orchitis Oophoritis

--------- virus is very very very infectious unlike mumps and varicella

Measles

After meningitis mumps can cause ----- and ------- which may be self limited Immunity:

Meningoencephalitis Unilateral deafness Permanent

MR of mumps is ------

Swelling of testicles caused by mumps is (common/uncommon)------ because of tunica albuginea unlike in ovaries but in both we have risk of -----

Uncommon | Infertility

T or F | Mumps can be transmitted through kissing

True

Measles is always ------, causes -------illness with -----, --- host , ---- serotype(s) Like mumps ----- is not effective because it's symptomatic before apearance of the ----- protection with mmr to measles is ---- while for rubella----

``` Symptomatic Febrile respiratory illness Macculopapular rash 1 host and 1 serotype Quaratine Rash >99% 92-95 ```

After secondary viremia rubeola virus this virus attacks 3 sites 1- 2- 3-

Skin: macculopapular face then trunk then limbs, coalescence with no scarring RT: cough , rhinitis Conjunctiva

In immunocompromised kids 1 in 1000 will develop------

Encephalitis

Rash appear after ----- the invasion of the virus while prdromal illness with the cough,----- and rhinitis appear after ------

2 weeks Koplik spots 1 week

In koplik spots we (can/can't) ------ detect the measles virus and ------ cells

Can (have viral antigens) | Multinucleated giant cells

Koplik spots are (pathognomonic/not) ------ for measles

Pathognomonic

Koplik spots colour:

Blueish to whitish

Giant cell pneumonia is present in ------patient

HIV

Modified measles

Measles infection to a patient with maternal immunity or taken 1 dose No koplik spots

T or F | Measles can cause otitis externa

False | Otitis media

PIE: MIBE: SSPE:

PIE: 7 to 28 days autoimmune targeting myelin and causing encephalitis then sequela MIBE: inclusions in nerves because of immune problems (defective immune sys) SSPE: from 5 to 15 years after infection because of multiplication in CNS without budding ( no M protein) this will lead to mental deterioration, involuntary movements , rigidity and coma This will happen for all patients infected with measles 3 years and the patient will die

Can we differentiate between macculopapular rash between measles and rubella clinically? Risk of mutation for measles?

No The only difference is that rubella rash disappears after 3 day None

``` MMR(V) Form: Doses: Risk of encephalitis for vaccinated: Risk of rash: ```

``` Live attenuated 1st dose 12-15 months (after maturation of thymus) 2nd dose 1.5 years till 3 Before school 1 in 1 million Present like in all vaccines ```

T or F | In Bacterial fever the patient usually looks more ill than viral one

Yes because it's usually more septic

Otitis media is a very common feature of ------ virus

Measles

Symptoms of measles:

Coryza (rhinitis)- cough-conjunctivitis Lymphopenia Koplik spots

Virology3 Flashcards

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