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Flashcards in vit deficiency Deck (15):
1

Vitamin

deficiency

2

vitamin A (retinol)

Night blindness; dry, scaly skin; corneal degeneration; Bitot spots on conjunctiva, immunosuppression

3

Vitamin B1 (thiamine)

wernickes: confusion, ophthalmoplegia, ataxia; also confabulation, personality change (due to damage to mamillary bodies)

dry beriberi: polyneuritis, symmetrical muscle wasting
wet beriberi: high output cardiac failure (dilated cardiomyopathy)

4

Vitamin B2 (riboflavin)

cheilosis (inflammation of lips, scaling and fissures at corners of mouth); corneal vascularization (2Cs of B2)

5

Vitamin B3 (niacin)

glossitis

pellagra: diarrhea, dementia, dermatitis (broad collar rash), hyperpigmentation of sun exposed limbs

severe deficiency caused by Hartnup disease (dec tryptophan absorption), malignant carcinoid syndrome (inc tryptophan metabolism) and isoniazid (low vit B6)

6

Vitamin B5 (pantothenic acid)

dermatitis, enteritis, alopecia, adrenal insufficiency

7

Vitamin B6 (pyridoxine)

convulsions, hyperirritability, peripheral neuropathy (deficiency inducible by isoniazid and OCPSs); can also have sideroblastic anemias due to impaired hemoglobin synthesis and iron excess

8

Vitamin B7 (biotin)

rare; dermatitis, alopecia, entertitis (due to antibiotic use or excessive ingestion of raw egg whites- b/c avidin binds it

9

Vitamin B9 (folate)

macrocytic, megaloblastic anemia; hypersegmented PMNs, glossitis (no neuro sxs) (labs: increased homocysteine)

deficiency is common (alcoholism, pregnancy); caused by several drugs (phenytoin, sulfonamides, methotrexate)

10

vitamin B12 (cobalamin)

NOTE: b12 has a very large reserve pool (Stored in liver); deficiency due to insufficient intake, malabsorption, lack of intrinsic factor (pernicious anemia), or absence of terminal ileum (SEE THIS S/P GASTRIC BYPASS OR CROHN SURGERY)

macrocytic, megaloblastic anemia; hypersegmented PMNs, paresthesias and subacute combined degeneration (degeneration of dorsal columns, lateral corticospinal tract, and spinocerebellar tracts) due to abnormal myelin

increased serum homocysteine and methylmalonic acid

11

Vitamin C (Ascorbic acid)

scurvy- swollen gums, bruising, petechiae, hemarthrosis, anemia, poor wound healing, perifollicular hemorrhages, corkscrew hair; weakened immune response

12

vitamin D

rickets in children (bone pain, deformity), osteomalacia in adults (bone pain, muslce weakness), hypocalcemic tetany

13

vitamin E

hemolytic anemia, acanthocytosis, muscle weakness, posterior column and spinocerebellar tract demyelination

(neuro sxs kind of like vit B12 deficiencyl byt no megaloblastic anemia, no hypersegmented PMNs, no increase in methylmalonic acid)

14

vitamin K

neonatal hemorrhage with increased PT and aPTT, but normal bleeding time; give K injecton at birth to prevent hemorrhagic disease of the newborn

15

zinc

delayed wound healing, hypogonadism, decrease in adult hair, weird taste in mouth, loss of sense of smell, acrodermatitis enteropathica (well demarcated, scaly plaques in intertriginous area)