Flashcards in W23-L12: Pathogenesis of Dementia Deck (7):
What risk factors for AD?
Genetics (APP mutations, Apo E) and age
What are the four basic types of Alzheimer's Disease?
What is the amyloid cascade hypothesis?
Aß aggregation causes amyloid plaque formation and normal clearance cannot remove these plaques
What is Aß synaptic toxicity?
Synaptic chaos arising from Aß monomers dispersing on membrane surfaces of neurone at extra and intra-synaptic sites
What imaging is used for Aß?
Is both variant CJD blood and sporadic-CJD blood infectious?
v-CJD is infectious, sCJD may be infectious