W23-L12: Pathogenesis of Dementia Flashcards Preview

Matt's Block 06 - Neuro block > W23-L12: Pathogenesis of Dementia > Flashcards

Flashcards in W23-L12: Pathogenesis of Dementia Deck (7):
1

What risk factors for AD?

Genetics (APP mutations, Apo E) and age

2

What are the four basic types of Alzheimer's Disease?

-Amnestic
-Visuospatial
-Aphasic
-Frontal

3

What is the amyloid cascade hypothesis?

Aß aggregation causes amyloid plaque formation and normal clearance cannot remove these plaques

4

What is Aß synaptic toxicity?

Synaptic chaos arising from Aß monomers dispersing on membrane surfaces of neurone at extra and intra-synaptic sites

5

What imaging is used for Aß?

C-PIB

6

Is both variant CJD blood and sporadic-CJD blood infectious?

v-CJD is infectious, sCJD may be infectious

7

What is the estimated incubation period of CJD?

At least 6-15 years

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