Flashcards in W23-L7: Ageing and Frailty Deck (10):
What is Cellular senescence?
where cells lose the
ability to divide
What is Organismal senescence?
The ageing of whole organisms
T/F Age is not the same throughout the whole body, one organ system could be more aged than another
What is the physiology behind ageing?
•Inevitable decline due to normal ageing
•Decreased reserve to respond to challenges
What is frailty?
Diminished ability to carry out the important practical and social activities of daily living
What is frailty associated with?
Low grade chronic inflammation with abnormalities of the endocrine and coagulation system
What is sarcopenia?
degenerative loss of skeletal muscle mass
What muscles fibres are lost more in ageing and frailty?
Type 2 (fast twitch) >> Type 1 fibre
What is Fried's Criteria?
1. Unintentional weight loss
4. Slow walking speed
5. Low physical activity