Flashcards in W22-L2: Regulating Dopamine Levels Deck (10):
In the extrapyramidal motor system acetylcholine and dopamine have what roles?
Acetylcholine: Excitatory input
Dopamine: Tonic inhibition
Motor signs of parkinson's disease
• Rigidity of limbs
• Impairment of postural reflexes
– Impassive, no blinking
– Monotonous, hypophonic
Non motor signs of parkinson's disease
• Cognitive deficiencies
• Raised anxiety levels
• Olfactory deficiencies
• Sleep disturbances
• Sexual dysfunction
• Bowel & bladder problems
What is the cause of Parkinson's disease and how much degradation is required?
Dopaminergic nerves in the substantia nigra degenerate, need 80% degeneration
T/F There is asymmetric degradation of substantia niagral dopamine neurones in parkinson's
What is the management of parkinson's disease?
Drugs provide symptomatic relief that attempt to Restore dopamine deficiency and restore dopaminergic / cholinergic balance in striatum.
What does L-Dopa do?
Provide substrate for dopamine synthesis
What do you give with L-Dopa?
An inhibitor of Peripheral Dopa decarboxylase to prevent L-Dopa's peripheral metabolism
What is a side effect of L-Dopa?
causes some of the dopaminergic neurones to die, possible due to increased ROS due to dopamine production from L-Dopa and these neurones can't handle it