W22-L2: Regulating Dopamine Levels Flashcards Preview

Matt's Block 06 - Neuro block > W22-L2: Regulating Dopamine Levels > Flashcards

Flashcards in W22-L2: Regulating Dopamine Levels Deck (10):
1

In the extrapyramidal motor system acetylcholine and dopamine have what roles?

Acetylcholine: Excitatory input

Dopamine: Tonic inhibition

2

Motor signs of parkinson's disease

• Tremor
• Rigidity of limbs
• Bradykinesia
• Impairment of postural reflexes
• Facial
– Impassive, no blinking
• Speech
– Monotonous, hypophonic

3

Non motor signs of parkinson's disease

• Cognitive deficiencies
• Depression
• Raised anxiety levels
• Olfactory deficiencies
• Sleep disturbances
• Fatigue
• Sexual dysfunction
• Pain
• Bowel & bladder problems

4

What is the cause of Parkinson's disease and how much degradation is required?

Dopaminergic nerves in the substantia nigra degenerate, need 80% degeneration

5

T/F There is asymmetric degradation of substantia niagral dopamine neurones in parkinson's

True

6

What is the management of parkinson's disease?

Drugs provide symptomatic relief that attempt to Restore dopamine deficiency and restore dopaminergic / cholinergic balance in striatum.

7

What does L-Dopa do?

Provide substrate for dopamine synthesis

8

What do you give with L-Dopa?

An inhibitor of Peripheral Dopa decarboxylase to prevent L-Dopa's peripheral metabolism

9

What is a side effect of L-Dopa?

causes some of the dopaminergic neurones to die, possible due to increased ROS due to dopamine production from L-Dopa and these neurones can't handle it

10

When wanting to restore dopaminergic-cholinergic imbalance when are muscarinic receptor antagonists used?

Only in conjunction with L-Dopa

Decks in Matt's Block 06 - Neuro block Class (48):