Flashcards in WBC Deck (43):
Number of WBC
Number of segmented neutrophils
Number of Band forms
3-5% (above 8% indicates left shift)
Number of Basophils
Number of Eosinophils
Number of Lymphocytes
Number of Monocytes
Where are all white blood cells made?
How are neutrophils made?
Myeloblasts to myelocytes (through mitosis)
How long does maturation of neutrophils take?
How is the maturation of neutrophils unique?
• If there is an increased demand- the maturation process can be sped up so that it doesn’t take as long
How long do neutrophils last in circulation?
Once neutrophils enter the tissue...
they never return to circulation
Where do neutrophils migrate?
To areas of infection or inflammation
T/F- Neutrophils can be bacteriocidal
Where are eosinophils attracted to?
Invasion from parasites and allergic reactions
What can eosinophils do to parasites?
Eosinophils can damage parasites and stop them from reproducing
When do basophils enter tissues?
Within several hours from being released into circulation
When are the levels of basophils elevated?
During hypersensitivity reactions
What do basophils bind to?
What is the role of basophils?
Breaks down the cytoplasm and releases histamine
How long do monocytes take to mature?
Are monocytes stored in the marrow?
How long do monocytes spend in the marrow before they enter the tissues?
What is the role of monocytes in the tissues?
-Function as macrophages
-Proliferate into the tissues
-Remove old RBC from circulation
-Process and present antigens to T and B lymphocytes
These are stem cells from bone marrow
What are the 2 types of lymphocytes?
T and B lymphocytes
Where do T cells differentiate?
What percentage of lymphocytes are T cells?
What percentage of lymphocytes are B cells?
What 2 groups are T cells divided into?
CD4 and CD8
These are receptors for signaling helper cells that signal to other immune cells
These are receptors for cytotoxic T cells
-They know when to kill and destroy a cells
These cells undergo differentiation in the bone marrow
What can B cells differentiate into? and when?
Plasma cells- after they interact with the antigen
These cells are part of innate immunity and they can cause lysis without previous antigen exposure
T/F- All types of lymphocytes can move freely between tissues and circulation
Can lymphocytes divide when activated?
Define differential count
The % of each white cell count
What can cause falsely high differential counts?
Presence of reticulocytes, giant platelets, or parasites that look like WBC
What can cause falsely low differential counts?
Leukemia or paraproteins
When are manual peripheral smears needed?
•To verify results
•To evaluate for WBC abnormalities
•To look for suspected low concentrations of abnormal cells
•To look for parasites and other organisms