Yonit diabetes 1 Flashcards

1
Q

What is the first reason for developing diabetes that is linked to obesity

A

Insulin resistance in liver white adipose tissues and skeletal muscle

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2
Q

How TZD drug may influence Patient’s weight

A

Increase it

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3
Q

Which gender usually develop diabetes faster in the same fat percentage

A

Men

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4
Q

which sex accumulate fat “healthier”?

A

Women

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5
Q

Which product are the primary cause for developing insulin resistance

A

Hepatic Diacylglycerol glycerol (DAG) and ceramide

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6
Q

How gluconeogenesis is affected in people who suffer from insulin resistance

A

It cannot be prevented

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7
Q

In type 2 diabetic, does caloric deficit helps only after reaching adequate BMI

A

No

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8
Q

What is the major contributor to insulin resistance

A

Adipose tissue Dysfunction

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9
Q

Does the number of Fat cells increases during obesity

A

Very little

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10
Q

Leptin receptor deficiency can cause

A

Obesity

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11
Q

How adiponectin influence inflamation

A

Lowers it

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12
Q

Does additional adiponectin giveaway helps the condition

A

No

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13
Q

-

A

Liver

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14
Q

How adiponectin influence insulin resistence

A

Lowers it

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15
Q

What are M2 macrophages

A

Noninflammatory macrophage that develop in healthy fat cell

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16
Q

What Are M1 macrophages

A

Inflammatory macrophages that are developed in unhealthy fat cells

17
Q

-

A

-

18
Q

Which inflammatory product and unhealthy fat cells secrete

A
Il6 
il8 
Leptin
Resistin
Monocyte
Mcp1
19
Q

Reduction of which anti-inflammatory factors is accompanies developing of unhealthy fats Cells

A

Il-10 and adiponectin

20
Q

How increase flexibility of extracellular matrix affect the tendency of fat cells to grow

A

Allows more increase in Fat cell volume

21
Q

How hif 1 alpha effect metabolic function

A

Badly