Alzheimer's Disease

Question 1

Pharmacological Treatment

Answer 1

1. Increase ACh (Cholinesterase inhibitors inhibit breakdown of ACh)
2. Decrease glutamate (NMDA Receptor Antagonists blocks glutamate binding)

Question 2

Aricept

Answer 2

Generic name: donepezil
Cholinesterase inhibitor (increases ACh)
Taken once daily
Tablets: 5mg, 10mg
Auxiliary label: swallow whole; do not crush or chew, should be taken with water
Requires LU for ODB coverage
RDT (Rapid Dissolve Tablets): 5mg, 10mg
Patients should allow RDT to dissolve on tongue before swallowing with water
Not covered by ODB

Question 3

Exelon

Answer 3

Generic name: rivastigmine
Cholinesterase inhibitor (increases ACh)
Take 1 capsule twice daily
Capsules: 1.5mg, 3mg, 4.5mg, 6mg
Requires LU for ODB coverage

Question 4

Reminyl

Answer 4

Generic name: galantamine
Cholinesterase inhibitor (increase ACh)
Usually taken once daily
ER (extended release) capsules: 8mg, 16mg, 24mg
Auxiliary labels: take with food, swallow whole; do not crush or chew
LU required for ODB coverage