NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)

Question 1

Common Facts

Answer 1

Commonly used to treat: pain with or without inflammation
Common adverse reactions: GI upset, ulcers, bleeding, fluid retention- can lead to hypertension (high blood pressure)
Common auxiliary labels: take with food

Question 2

Mechanism of Action

Answer 2

Inhibit action of COX (cyclooxygenase)
Decrease prostaglandin synthesis
-Prostaglandins involved in pain and inflammation
Notes:
-Analgesic= relieves pain
-Anti-inflammatory= relieves inflammation
-Antipyretic= relieves fever

Question 3

Advil, Motrin

Answer 3

Generic name: ibuprofen
Tablets: 200mg, 300mg, 400mg, 600mg
200mg= "regular strength" OTC
400mg= "extra strength" OTC
600mg= NAPRA Schedule I
Commonly dosed 200mg-800mg Q4-6H PRN
Maximum dose= 3200mg per day

Question 4

Ansaid

Answer 4

Generic name: flurbiprofen

Tablets: 50mg, 100mg

Question 5

Clinoril

Answer 5

Generic name: sulindac

Tablets: 150mg, 200mg

Question 6

Feldene

Answer 6

Generic name: piroxicam

Capsules: 10mg, 20mg

Question 7

Indocid

Answer 7

Generic name: indomethacin
Capsules: 25mg, 50mg
Often dosed TID

Question 8

Mobicox

Answer 8

Generic name: meloxicam
Tablets: 7.5mg, 15mg
Often dosed BID

Question 9

Naprosyn; Anaprox

Answer 9

Generic name: naproxen

Often dosed BID

Question 10

Orudis

Answer 10

Generic name: ketoprofen

Keto-E- enteric coated tablets

Question 11

Toradol

Answer 11

Generic name: ketorolac
Tablets: 10mg
Injection: 10mg/mL, 30mg/mL
Commonly dosed Q4-6H PRN
Maximum dose= 40mg per day