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Flashcards in 1.16 Pain Deck (7)
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1

Describe the characteristics of an A delta pain fibre...

• 1-5 micrometers
• Thin myelination
• Fast conduction speed - 20m/s
• SHarp, fast pain
• Responds to mechanical stimulation, painful heat/cold

2

Describe the characteristics of a C pain fibre...

• 2.5 micrometers
• No myelination
• 2m/s - slow
• Dull slow ache
• Same as Ad plus substances from damaged tissue
(multimodal)

3

What are the different Rexed's Laminae?

I = Marginal Zone
II/III = Substantia Gelatinosa
IV-VI = Nucleus proprius

4

Where do the pain fibres synapse? And where do they ascend to after?

A delta - synapse lamina 1&5
C fibre - synapse lamina 1&2

Lamina 4,5,6 -> Thalamus anterolateral tract

5

Define allodynia...

When peripheral sensitisation occurs, threshold lowers for non-noxious stimuli

6

Define hyperalgesia...

When peripheral sensitisation occurs, threshold lowers and responsiveness increases for noxious stimuli

7

What is central sensitisation?
Where can this occur?

Sensitisation in the spinal cord due to a change in the post synaptic neurone.
• Spinal Cord (lamina I and V neurones)
• Thalamus
• Amygdala
• Anterior cingulate cortex.