Drugs Used To Treat Leprosy

Question 1

Two principal forms which mycobacterium leprae occurs

Answer 1

Lepromatous leprosy
Tuberculoid leprosy

Question 2

Lepromatous leprosy is characterised by

Answer 2

Skin lesions and symmetrical involvement of the peripheral nerves

Question 3

Nerve lesions in tuberculoid tuberculosis are

Answer 3

Asymmetrical

Question 4

Between the two principal forms of m.leprae which is more contagious

Answer 4

Lepromatous leprosy

Question 5

What are the classes of drugs used in treatment of leprosy

Answer 5

Sulphones eg; dapsone
Antibiotics eg; rifampicine
Phenazines Eg; clofazimine
Thiosemicarbazones eg; amithiozin
Sedatives eg; thalidomide

Question 6

AMPCA of sulphone(Dapsone)

Answer 6

A— bacteriostatic
MOA— inhibition of folic acid synthesis
Pharmacokinetics— given orally. Distributed throughout the body. Acetylated in the liver
Clinical uses— pneumocystis carinae, tuberculosis and leprosy
Adverse effects—- hemolysis, hypoxia, insomnia

Question 7

The weekly dose of dapsone in the beginning is……… and this eventually increases to weekly dose of………

Answer 7

25mg
400- 600mg

Question 8

Rifampicine is ……….. to m.leprae

Answer 8

Bacteriocidal

Question 9

What is the monthly dosage of rifampicine needed in the combination therapy for treatment of leprosy

Answer 9

600mg

Question 10

AMPCA of chlofazimine

Answer 10

A— treatment of sulphone resistant M.leprae
M— blocks template function of DNA
P — taken orally , accumulates at the reticuloendothelial tissues, excreted in faeces
C— prevents development of erythema nodosum leprosum, used in combination therapy
A— Red discolouration of skin

Question 11

A sedative hypnotic drug effective in the treatment of Erythema nodosum leprosum

Answer 11

Thalidomide

Question 12

The use of thalidomide is limited because of

Answer 12

It’s teratogenic effects

Question 13

Amithiozone exerts its tuberculostatic more on which principal form of leprosy

Answer 13

Tuberculoid form