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Pharmac > Endocrine Pharmacology(Ovary And Testis) > Flashcards

Endocrine Pharmacology(Ovary And Testis) Flashcards

1
Q

What are the hormones of the ovary?

A

Oestrogen
Progesterone
Inhibin
Activin
Relaxin (responsible for growth.Inhibits Uterine Contraction)
Androgens

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2
Q

What is the primary function of the androgens

A

Hair growth in Females

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3
Q

Example of Androgens

A

Testosterone
Dehydroepiandrosterone
Androstenedione

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4
Q

The change of ovarian function at puberty is called

A

Gonadarchy

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5
Q

What cells of the follicles secrete estrogen under the influence of LH

A

Outer theca and inner granulosa

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6
Q

Estrogen function reaches its peak when

A

Just before mid cycle

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7
Q

The cavity of the ruptured follicle would be filled with blood known as

A

Corpus hemorrhagica

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8
Q

In menopause, Estrogen production comes from

A

Conversion of adrenal and ovarian steroids such as androstenedione to estrone and estradiol

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9
Q

Types of Estrogen

A

Natural Estrogen
Steroidal Synthetic Estrogen
Non steroidal Synthetic Estrogen

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10
Q

Examples of natural Estrogen

A

Estradiol E2
Estrone E1
Estriol E3

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11
Q

The major natural estrogen secreted by Women is

A

Estradiol

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12
Q

Steroidal Synthetic Estrogen

A

Ethinyl estradiol
Mestranol
Quinestrol

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13
Q

Non Steroidal Synthetic Estrogen

A

Diethylstibestrol
Dienestrol
Hexestrol
Benzestrol

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14
Q

The Undesirable Side effect associated with the hepatic effect of Estrogen is

A

Increased Synthesis of clotting Factors

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15
Q

What is the mech of action of estrogen

A

Binds to Intracellular estrogen receptors in the nucleus of a cell leading to protein synthesis

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16
Q

The most important progestine in women is

A

Progesterone

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17
Q

Progesterone is a ……… carbon compound

A

21

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18
Q

Estrogen and testosterone are …………. and ………… carbon compounds respectively

A

18 and 19

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19
Q

Progesterone serves as a precursor for

A

Estrogen
Androgen
Adrenocortical Steriods

20
Q

First gen progesterone

A

Norethisterone

21
Q

Second gen progesterone

A

Norgestrel
Levonorgestrel

22
Q

Third gen progesterone

A

Doxogestrel

23
Q

4th gen Progesterone

A

Drospirenone

24
Q

The third and fourth generation progesterone have less side effects because

A

They don’t have Androgens

25
Q

Therapeutic uses of Progesterone

A

Hormone replacement therapy
Treatment of dysmenorrhea
Treatment of Endometriosis

26
Q

In the use of Progesterone as a test of estrogen Secretion, what quantity and alternative drug is used

A

Progesterone 150mg/day
Medroxyprogesterone acetate 10mg/day

5 to 7days

27
Q

The first selective estrogen receptor modulator

A

Tamoxifen

28
Q

Example of SERM(Selective Estrogen Receptor modulator) drugs are;

A

Tamoxifen
Raloxifen

29
Q

Why is Raloxifene preferred to tamoxifen

A

It’s inability to cause Endometrial Cancer/hyperplasia

30
Q

Ovulation Induction agents

A

Clomiphene Citrate
Letrozole/Anastrozole

31
Q

Mifepristone is used as an abortifacient when combined with

A

Misoprostol

32
Q

Progesterone receptor modulators used as Contraceptive

A

Ulipristal
Mifepristone

33
Q

What produces testosterone and under the influence of what hormone

A

Leydig cells
Luetinizing hormone

34
Q

Testosterone is bound majorly to…………. In the blood

A

Sex hormone binding globulin

35
Q

An estrogen inhibitor also a weak androgen used in the treatment of endometriosis

A

Danazol

36
Q

Infertility is

A

The Inability of a couple to achieve pregnancy after one year of regular, adequate and unprotected coitus

37
Q

Mech of Action of clomiphene citrate

A

Competitive Inhibitor of endogenous Estrogen…leading to increased gonadotrophin secretion

38
Q

Name the Fertility Drugs

A

Clomiphene citrate
Letrozole/Anastrozole
Metformin
Dopamine agonist:bromocriptine
Human Menopausal Gonadotropin

39
Q

Mech of action of Letrozole/Anastrozole

A

Irreversible inhibition of aromatase enzyme

40
Q

Where does metformin act as a fertility drug

A

In patients with PCOS…corrects the insulin insensitivity

41
Q

Menstropine…what is it?…where is it gotten from

A

Mixture of LH and FSH
Urine of post menopausal women

42
Q

Two preparation for oral contraceptives are

A

COC- Combined Oral Contraceptive
POP- Progesterone Only pill

43
Q

Combined Oral Contraceptive Example

A

Ethynl Estradiol

44
Q

Example of POP

A

Depotmedroxyprogesterone acetate(DMPA)
Hormonal IUCD

45
Q

Why POP is preferred over COC

A

It has less side effects

Pharmac (27 decks)

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