Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmac > Adrenergic System > Flashcards

Adrenergic System Flashcards

1
Q

Phosphatidylinositol 4,5-bisphosphate (PIP2) is cleaved into two second messengers:

A

diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Mechanism of alpha 1 action

A

•Binding of agonist
•Activation of Gprotein
•Activation of phospholipase C…..cleaving of PIP2 to DAG and IP3
•Release of intracellular Calcium
•Activation of protein kinase C and calcium calmodulin complex which activates MLCK
•MLCK phosphorylate mlc leading to contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Beta 1 receptors are primarily found in the

A

Heart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the effect of beta 2 receptor activation in the bronchi

A

Bronchodilation- relaxation of smooth muscles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Isoprenaline is a ……… receptor agonist and has no effect on ……….. receptor

A

Beta
Alpha

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Examples of a direct acting alpha 1 agonist

A

Methoxamine
Phenylephrine
Meturamin
Mephenteramine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Use of direct acting alpha 1 agonist

A

•Nasal decongestion
•Management of hypotension due to overdose
•Blood pressure elevation during spinal anaesthesia
•Combined with local anesthetics to prolong effect
•Mydraitic agents

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Example of direct acting alpha 2 agonist

A

Brimonidine
Apraclonidine

Clonidine
Guanabenz
Guanfacine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

A side effect of alpha 2 agonists

A

Sexual dysfunction
Rebound htn
Bradycardia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

An example of a B1 agonist is

A

Dobutamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

…………….. is a non selective beta agonist

A

Isoprenaline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Beta 2 agonists Include

A

Salbutamol
Terbutaline
Fenoterol
Albuterol
Levalbuterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

The indirect acting sympatomimetics are

A

Amphetamine
Metamphetamine
Methylphenidate
Cocaine
Ephedrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Example of an alpha 2 selective blocker used to improve sexual performance

A

Yohimbine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Non selective alpha receptor blockers

A

Phenoxybenzamine
Phentalamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Alpha 1 receptor inhibitors

A

Prazosin
Doxazosin
Terazosin
Trimazosin

17
Q

Alpha receptor antagonists are used to treat

A

Pheochromocytoma
Chronic HTN
Hypertensive emergencies
HTN due to pheochromocytoma
Symptoms of BPh

18
Q

Beta 1 selective antagonists are

A

Metoprolol
Atenolol
Alprenolol
Esmolol

19
Q

Non selective beta blockers

A

Propanalol
Nadolol
Pindolol
Timolol

20
Q

Selective beta 2 blockers

A

Butoxamine

21
Q

Beta blockers are used in the treatment of

A

HTN
IHD
Heart failure

22
Q

Neuronal uptake is inhibited by

A

Tricyclic antidepressants

23
Q

Tyrosine hydroxylase is inhibited by

A

Metyrosine

24
Q

Direct acting sympathomimetics

A

Metaraminol
Mephentamine
Methoxamine
Phenylephrine
Epinephrine

Pharmac (27 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions