Tetracycline And Chloramphenicol Flashcards
1
Q
What is the MOA of tetracycline
A
Inhibits bacterial protein synthesis by competing with tRNA for the A site of the
ribosome and reversibly inhibiting its binding to the mRNA codons in the 30s subunit.
2
Q
Chloramphenicol belong to a group of compounds known as
A
Macrolides
3
Q
Low level Resistance to chloramphenicol
A
Selection of mutants less permeable to the drug
4
Q
High level of resistance to chloramphenicol is by
A
Production of chloramphenicol acetyl transferase which is plasmid encoded
5
Q
MOA OF Chloramphenicol
A
Inhibits protein synthesis by binding to the 50s subunit of bacterial chromosome and prevent peptide bond formation
