Antiplatelets, Antithrombotics And Fibrinolytics

Question 1

The current antiplatelets in clinical use are designed to

Answer 1

Inhibit cyclooxygenase 1(cox-1 inhibitors)

To inhibit gpIIb/IIIa receptors (gpIIb/IIIa receptor blocker)

ADP receptor inhibitors

Question 2

Example of a COX-1 inhibitor

Answer 2

Aspirin

Question 3

MOA of aspirin as an anti platelet

Answer 3

Inhibits the synthesis of TXA2 by irreversible acetylation of the enzyme COX-1 and Thromboxane synthase

Question 4

Why should the dose of clopidogrel be individualized?

Answer 4

Because there’s an Isoform of CYP450 known as CYP2C19 responsible for activating clopidogrel as a pro-drug

Question 5

What drug impairs the CYP2c19 activity

Answer 5

Omeprazole

Question 6

An example of a gpIIb/IIIa receptor blocker

Answer 6

Abciximab

Question 7

MOA of gpIIb/IIIa receptor like Abciximab

Answer 7

Binds and occupies the receptor

Question 8

A vasodilator that inhibits platelet function and is coadminstered with aspirin/warfarin to prevent thromboemboli

Answer 8

Dipyridamol

Question 9

Example of vasodilators with phosphodiesterase activity

Answer 9

Dipyridamol
Cilostazol

Question 10

Example of fibrinolytic agents

Answer 10

Stretokinase
Urokinase
Retplase
Anistreplase
Tenecteplase
Alteplase

Question 11

MOA of fibrinolytic drugs

Answer 11

Mimic endogenous tPA

Question 12

What inhibits the conversion of plasminogen to plasmin

Answer 12

Alpha 2 antiplasmin

Question 13

Which fibrinolytic drug is a purified protein from beta hemolytic streptococcus

Answer 13

Streptokinase

Question 14

Examples of antifibtinolytics

Answer 14

Tranexamic Acid
Amino caproic Acid

Question 15

Amino caproic acid is used as a treatment for

Answer 15

Prostatectomy

Question 16

Antidote for the overdose of heparin

Answer 16

Protamine