Classificafion Of Drug Receptor Interaction

Question 1

Types of agonists

Answer 1

Full agonist
Partial agonist
Inverse agonist

Question 2

In full agonist the response is ……… one

Answer 2

Equal to

Question 3

In partial agonist the intrinsic activity is

Answer 3

Greater than zero less than one

Question 4

Mechanism of agonism

Answer 4

Synergism
Summation/additivity
Potentiation

Question 5

The mechanisms of antagonism

Answer 5

Pharmacokinetic antagonism
Chemical antagonism
Physiologic/Functional antagonism
Competitive antagonism
Reversible antagonism

Question 6

Physiologic antagonism is defined as

Answer 6

Drugs/antagonists acting on a separate receptor to initiate effects that are functionally opposite to the antagonist

Question 7

What are spare receptor?
When are receptors said to be spare

Answer 7

Receptors are said to be spare for a pharmacologic response….if it is possible to elicit maximal biologic response at a concentration of agonist that does not result in full occupancy of the available receptors

Question 8

What are orphan receptors

Answer 8

These are receptors whose ligands have not been produced or known at present

Question 9

Potency

Answer 9

Amount of drug needed to produce an effect

It is a measure of drug activity expressed in terms of amount required to produce an effect of a given intensity