Flashcards in 1.3 - Cleft Lip +/- Palate Deck (39)
What kind of disorder is Cleft Lip +/- Palate?
Disorder caused by interaction of multiple genes with environmental influences
How frequently do clefts occur?
1 in 595 births
How many Clefts are Lip only?
How many of these are Unilateral?
How many are on the Left Side?
25% lip only
80% are unilateral
70% of the time it is on the left)
How many Clefts are Palate only?
25% palate only
How many Clefts are Lip + Palate?
50% lip and palate
In which Ethnicity are clefts most common?
Which Ethnicities are the next common? (3)
Asians -> Caucasians -> African Americans
Which Gender experiences more Combination Clefts (Lip + Palate)?
Which Gender experiences more Severe Forms of cleft?
Which Gender experiences more Palatal Clefts?
What percentage of individuals with Cleft have at least one other abnormality?
(Varies based on cleft type)
What percentage of individuals with Cleft of the Lip Only have at least one other abnormality?
What percentage of individuals with Cleft of the Lip + Palate have at least one other abnormality?
What percentage of individuals with Cleft of the Palate Only have at least one other abnormality?
How does Parental Age affect the risk of Cleft?
No direct effect
How does Birth Order affect the risk of Cleft?
No direct effect
What is the Etiology of Cleft?
Cause of birth defect is due to Multifactoral Inheritance:
Predisposition is exasperated by environmental factors
(Genetic + Environmental)
How does Genetics/Family History increase one's risk of Cleft?
If mother or father has cleft palate and one child already has cleft palate, next child is 17% likely to have cleft palate!
What Environmental Factors/Teratogens increase one's risk of Cleft?
Drugs (Valium, dilantin, acutane)
Insufficient folic acid
How many Clefts are estimated to be due to Inheritance?
How many Clefts are estimated to be due to Chromosomal Influences?
How many Clefts are estimated to be due to Environmental Factors or Unknown?
What is a Complete Cleft?
What does it include? (4)
Goes all the way into nose
At what point is development interrupted to cause a Complete Cleft?
Before the 9th week
What is a Incomplete Cleft?
Doesn't go into the nose entirely
At what point is development interrupted to cause a Incomplete Cleft?
During 9th week
What is a Unilateral Incomplete Cleft of the Lip Only?
An incomplete cleft on one side only
What is a Bilateral Incomplete Cleft of the Lip Only?
An incomplete cleft on both sides
What is a Unilateral Complete Cleft of the Lip Only?
A complete cleft on one side only
What is a Bilateral Complete Cleft of the Lip Only?
A complete cleft on both sides