1.3 - Cleft Lip +/- Palate Flashcards Preview

ECU Craniofacial Anomalies + Laryngeal Rehab > 1.3 - Cleft Lip +/- Palate > Flashcards

Flashcards in 1.3 - Cleft Lip +/- Palate Deck (39):
1

What kind of disorder is Cleft Lip +/- Palate?

(2)

Multi-factorial Inheritance:

Disorder caused by interaction of multiple genes with environmental influences

2

How frequently do clefts occur?

1 in 595 births

(CDC, 2006)

3

How many Clefts are Lip only?

How many of these are Unilateral?

How many are on the Left Side?

25% lip only

80% are unilateral

70% of the time it is on the left)

4

How many Clefts are Palate only?

25% palate only

5

How many Clefts are Lip + Palate?

50% lip and palate

6

In which Ethnicity are clefts most common?

Which Ethnicities are the next common? (3)

Native Americans

Asians -> Caucasians -> African Americans

7

Which Gender experiences more Combination Clefts (Lip + Palate)?

Males

8

Which Gender experiences more Severe Forms of cleft?

Males

9

Which Gender experiences more Palatal Clefts?

Females

10

What percentage of individuals with Cleft have at least one other abnormality?

14-15%

(Varies based on cleft type)

11

What percentage of individuals with Cleft of the Lip Only have at least one other abnormality?

7%

12

What percentage of individuals with Cleft of the Lip + Palate have at least one other abnormality?

14%

13

What percentage of individuals with Cleft of the Palate Only have at least one other abnormality?

24%

14

How does Parental Age affect the risk of Cleft?

No direct effect

15

How does Birth Order affect the risk of Cleft?

No direct effect

16

What is the Etiology of Cleft?

(2)

Cause of birth defect is due to Multifactoral Inheritance:

Predisposition is exasperated by environmental factors

(Genetic + Environmental)

17

How does Genetics/Family History increase one's risk of Cleft?

If mother or father has cleft palate and one child already has cleft palate, next child is 17% likely to have cleft palate!

18

What Environmental Factors/Teratogens increase one's risk of Cleft?

(4)

Drugs (Valium, dilantin, acutane)

Smoking

Insufficient folic acid

Maternal diabetes

19

How many Clefts are estimated to be due to Inheritance?

20%

20

How many Clefts are estimated to be due to Chromosomal Influences?

3-5%

21

How many Clefts are estimated to be due to Environmental Factors or Unknown?

65%

22

What is a Complete Cleft?

What does it include? (4)

Goes all the way into nose

//

Lip

Alveolus

Hard palate

Velum

23

At what point is development interrupted to cause a Complete Cleft?

Before the 9th week

24

What is a Incomplete Cleft?

Doesn't go into the nose entirely

25

At what point is development interrupted to cause a Incomplete Cleft?

During 9th week

26

What is a Unilateral Incomplete Cleft of the Lip Only?

An incomplete cleft on one side only

27

What is a Bilateral Incomplete Cleft of the Lip Only?

An incomplete cleft on both sides

28

What is a Unilateral Complete Cleft of the Lip Only?

A complete cleft on one side only

29

What is a Bilateral Complete Cleft of the Lip Only?

A complete cleft on both sides

30

What is a Bilateral Incomplete Cleft of the Palate Only?

A cleft of the palate that does not include the lips or alveolus.

31

What are the 6 Levels of the Kernahan Striped-Y Classification?

Nose

Nasal Floor

Lip

Alveolus

Hard Palate

Soft Palate

32

What are two other forms of Cleft?

Soft Palate Only

Holoprosencephaly (Midface Cleft)

33

What is the Primary Palate?

Lip + alveolar process

34

How can the Primary Palate be affect by Cleft?

(2)

Can be complete or incomplete

Unilateral or bilateral

35

What is the Secondary Palate?

Hard + soft palate (area posterior to incisive foramen)

36

How can the Secondary Palate be affect by Cleft?

Can be complete or incomplete

37

What is a Submucous Cleft?

Cleft of soft palate where mucous membrane is intact

38

What words are associated with Submucous Cleft?

(5)

Bifid uvula

Furrow along midline

Zona pellucida

Bony notch where posterior nasal spine should be

Anterior insertion of levator muscle

39

Muscle abnormalities....

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