11.1 Serologic test for Infectious Mononucleosis Flashcards
Viral disease common among college students which is also known as : Kissing Disease, Glandular Fever, Mono; Pfeiffer’s Disease
infectious mononucleosis
Causative agent of IM?
Epstein Bar Virus
Epstein Barr Virus is a RNA virus that belongs to Herpesviridae
T or F
F
DNA
EBV targets specifically T cell
T or F
F
B cell
In hematologic Parameters:
Monocytes and Lymphocytes are decreased
T or F
F
Increased
In hematologic Parameters:
Presence of Atypical lymphocytes or reactive B cells
T or F
F
T cells
In hematologic Parameters:
reactive T lymphocyte is also known
Downey cells
In hematologic Parameters:
reactive T lymphocyte kills B cells
T or F
T
In hematologic Parameters:
Appearance of Downey Cell
a. Ballerina Skirt
b. Dancer skirt
c. Ballerina dress
a
Cross reacting antibodies that can react with antigen of another or different species
Heterophile Antibodies
3 types of Heterophile Ab:
Produced when injected with immune globulins
a. Forssman
b. Serum Sickness (SS)
c. IM
b
3 types of Heterophile Ab:
normally present in the body in low levels
a. Forssman
b. Serum Sickness (SS)
c. IM
a
3 types of Heterophile Ab:
associated to the disease
a. Forssman
b. Serum Sickness (SS)
c. IM
c
Test to detect:
Monospot test (Citrated Horse Cells Test)
Paul Bunnell Test = Screening test
Davidsohn Differential test = Confirmatory test
T or F
T
Problems with Heterophile AB test?
Not specific
Usually negative after recovery (Positive when acute phase)
T or F
T
