Pathology of obstuctilve lung disease Flashcards
what type of hypersensitivity is astma
1
what cells are responsible for an astma attack
mast
what defincity makes you more suspecepitle to bronchitei and empyseam
aplah - 1 antiporase - antrypsin
what is the clincal definition for chronci bronchitis
cough producitve of pspum most days in at least 3 consequctim months for 2 or more consecutive years
what change does broncitis cause in large and small aiway
large airways, mough gland hyperplaia, goblet cell hyperplasia, inlmation and fibrosis is a minor complone
small airway, increase in goblet cells, inflatm and fibrosis
what is emphysema
destuction of teh bronchile walls or dilationi of the bricon to increase airsawpce between ternal bonchiloes
centriacinar ephyiam
damage to lung tisssues concentrated around respiarty bonciles yet presergin disalt alvelar duct and alveoli
panacinar emphysema
associated with a1 antitrypsin decion, this destruction affect the whole acinus
acinus
part of the lung contain aveloar duct, sac and blood vessels in the area and alveli
Pericinar emphyseam
creasts a bulla, a large bulk under teh pleura, it is assoicaed with enlargment of the airspace at the edge of the acinar unit
what does smoing cause to antiproseaw
an inbalacne due to increased amounts of it
function of alpha 1 antiryspin
stops the breasdoin of eleastic proti by elastase In the lung. this prevent neurophils from damaging the lung when there is lots of infection
what is refersibel in copd
the smooth musle tone and inflmation
why does hypoxaemia occur in cop
reduced respiraty drive, loss of alelar sace, shunt
why do vessles constict in cop
due to lack of airflwo, this means that there is pulmonary hypertension in the lungs
core pulmonale
increase in the right side of the heart due to pulmonary hyperentions
what is a secondary effect of pulmary hpertnesion
polycythaemeae