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Flashcards in 2013 biochem endterm Deck (39)
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1

Which of the following zygomens is activated by autocatalysis in our body?
A) Pepsinogen
B) Chymotrypsinogen
C) Proelastase

A) Pepsinogen

2

How does our body appose ketoacidosis during prolonged starvation?
A) increase production of ketone bodies
B) increase activity of urea cycle
C) increase release of ammonia from glutamine by the kidneys
D) Increase lipogenesis

C) increase release of ammonia from glutamine by the kidneys

3

Where can you find complex carbohydrates in the plasma membrane?
A) Inner core
B) extracellular surface
C) Core leaflet
D) Intracellular surface

B) extracellular surface

4

Phenylketonuria is what type of inborn error of metabolism?
A) amino acid metabolism
B) carbohydrate metabolism
C) lipid metabolism
D) purine metabolism
E) pyrimidine metabolism

A) amino acid metabolism

5

What kind of mutation is mostly found in phenylalanine hydroxylase in PKU?
A) Deletion
B) Missense
C) Insertion
D) Splice

B) Missense

6

Cystic fibrosis is what type of inborn error of metabolism?
A) amino acid metabolism
B) carbohydrate metabolism
C) lipid metabolism
D) purine metabolism
E) pyrimidine metabolism

A) amino acid metabolism

7

What is the genetic cause of cystic fibrosis?
A) Missense
B) Insertion
C) Deletion
D) Splice

C) Deletion

8

What is the use of ketones bodies during prolonged starvation?
A) Energy production in the brain
B) Energy production in the liver
C) Gluconeogenesis

A) Energy production in the brain

9

Which of the following can be converted to 2-deoxyribose?
A) Adenosine
B) AMP
C) ATP
D) ADP

D) ADP

10

What produces ketone bodies during prolonged starvation ( >21 days)?
A) Glycerol from adipose
B) fatty acids from adipose
C) Lactic from RBC
D) Branches chain amino acids from skeletal muscle

B) fatty acids from adipose

11

What increases the fluidity in the plasma membrane?
A) Cis-unsaturated fatty acids
B) Trans-unsaturated fatty acids
C) Integral proteins

A) Cis-unsaturated fatty acids

12

What is the most common product of transamination reactions?
A) Alanine
B) Pyruvate
C) Leucine
D) Glutamate
E) Trytophan

D) Glutamate

13

What is the characteristic of aminotransferase?
A) must have glutamine or alpha-ketoglutarate
B) always net production of glutamate
C) can't catalyze essential amino acids
D) uses pyridoxal phosphate as a cofactor

D) uses pyridoxal phosphate as a cofactor

14

What carbohydrates is used in both de-novo synthesis of purine & salvage pathways?
A) Ribose-5-phosphate
B) Phosphribosylpyrophosphate
C) Adenosine

B) Phosphribosylpyrophosphate

15

What is the most acidic phospholipid in the cell?
A) cardiolipin
B) sphingomyelin
C) PS
D) PC

A) cardiolipin

16

Which of these is a feature of Trans fats?
A) Absence in the mother’s milk
B) good substrate for lipase
C) Long half life
D) Can’t be absorbed by small intestine
E) Rapid degradation in the saliva

C) Long half life

17

which set of desaturases are present in our body?
A) ∆ 4,5,6,9 desaturases
B) ∆ 3,5.6.9 desaturases
C) ∆ 4,6,9,12 desaturases

A) ∆ 4,5,6,9 desaturases

18

which lipase needs a colipase?
A) pancreatic lipase
B) phospholipase C
C) hepatolipase
D) hormone sensitive lipase

A) pancreatic lipase

19

What facilitates the packing of good cholesterol into HDL?
A) Cardiolipin
B) Leukotrienes
C) Phosphotidylcholine
D) LCAT

D) LCAT

20

What is the effect of prolonged trans-fat consumption?
a. Suppressing the activity of LDL receptors
b. Activating the activity of LDL receptors

a. Suppressing the activity of LDL receptors

21

Inhibition of which protein function results in an increase in HDL cholesterol & decrease in LDL cholesterol simultaneosly?
A) ApoE receptor
B) CETP
C) INSIG
D) LDL receptors
E) SCAP

B) CETP

22

Which of these substances cannot be absorbed from the GI tract?
A) Trans Fatty acid
B) Olestra
C) cis fatty acid

B) Olestra

23

Which substance enhances the oxidation of odd-chain fatty acid?
A) ATP
B) Citrate
C) Vitamin B12
D) NAD+

C) Vitamin B12

24

What is the normal physiological function that will be affected if we block farnesylation of RAS protein to slow down cancer rate?
A) Alpha oxidation
B) Beta oxidation
C) glycosyl phosphatiydl inositol formation
D) HDL receptor acylation
E) Cholesterol formation

E) Cholesterol formation

25

What is the main regulator of the
Pentose Phosphate Pathway?
A) NADP+/NADPH
B) AMP/ATP
C) NAD+/NADH
D) Glucose 6-Phosphate

A) NADP+/NADPH

26

The lack of fructokinase causes fructose intolerance even though hexokinase catalyzes the phosphorylation of fructose. What property of hexokinase causes fructose intolerance?
A) high Km for fructose
B) low Vmax
C) feedback inhibition by fructose 6 phosphate
D) feedback inhibition by glucose 6 phosphate

A) high Km for fructose

27

What is produced in Fenton reaction?
A) Hydroxyl radical
B) Hydrogen peroxide
C) Superoxide radical
D) Peroxinitrite

A) Hydroxyl radical

28

What are ketone bodies used for?
A) Energy production in the brain
B) Energy production in the liver
C) Gluconeogenesis in the kidney
D) Fatty acid synthesis in adipose tissue

A) Energy production in the brain

29

What increases respiration?
A) ADP
B) NADH
C) FADH2
D) queinone

A) ADP

30

What product of PPP is critical for antioxidants function in the cell?
A) NADPH
B) ATP
C) Ribose-5-phosphate

A) NADPH