The Rest of the DNA Viruses Flashcards

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0
Q

What can POXviridae cause?

A
  1. Smallpox

2. Molluscum contagiosum

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1
Q

What is the morphology of POXviridae?

A
  1. Complex coat
  2. Double-stranded linear DNA
  3. The only DNA virus to replicate in cytoplasm
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2
Q

What happens in smallpox?

A

Skin lesions and death - this disease has been eradicated from the earth! :)

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3
Q

What happens in molluscum contagiosum?

A

Small white bumps with a central dimple (like a wart). Often found in the genital region.

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4
Q

What is useful to keep in mind about POX-viridae?

A
  1. No animal reservoirs

2. Codes for DNA and RNA polymerases.

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5
Q

What is the morphology of PAPOVAviridae?

A
  1. Naked icosahedral
  2. Double-stranded circular DNA
  3. Replicates in nucleus
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6
Q

What are the 3 main pathogenic PAPOVAviridae?

A
  1. HPV
  2. BK polyomavirus
  3. JC polyomavirus
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7
Q

What can HPV cause?

A
  1. Common warts - types 1,2,4,7.
  2. Genital warts - types 6,11,16,18 + others.
  3. Laryngeal warts - types 6,11.
  4. Cervical cancer - types 16,18.
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8
Q

What does BK polyomavirus cause?

A
  1. Kidney disease in renal transplant patients.

2. Hemorrhagic cystitis in bone marrow transplant patients, and mild respiratory illness in children.

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9
Q

What can JC polyomavirus cause?

A

Progressive multifocal leukoencephalopathy, characterized by degenerative CNS white matter disease.

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10
Q

What are the main methods of wart removal?

A
  1. Liquid nitrogen (freeze them off) - best method.
  2. Surgical
  3. Electrosurgery (laser ablation)
  4. Podophyllin - for genital warts.
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11
Q

What is useful to keep in mind about warts?

A
  1. Many warts resolve spontaneously in 1-2 years.

2. Relapses are common after treatment, because HPV DNA is found in normal appearing tissue around the wart.

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12
Q

What is interesting to remember about PAPOVAviridae?

A

Second smallest DNA virus.

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13
Q

What is the morphology of ADENOviridae?

A
  1. Naked icosahedral
  2. Double-stranded linear DNA
  3. Replicates in nucleus
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14
Q

What can ADENOviridae cause?

A
  1. Childhood upper respiratory tract infections (rhinitis, sore throat, fever, conjunctivitis).
  2. Epidemic keratoconjunctivitis (pink eye).
  3. Epidemic diarrheal illness in infants and children.
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15
Q

What is important to remember about the problems caused by ADENOviruses?

A

They are self limited.

16
Q

What is the morphology of PARVOviridae strain B19?

A
  1. Naked icosahedral
  2. The only single stranded linear DNA virus (negative stranded).
  3. Replicates in nucleus
17
Q

What can PARVOviridae strain B19 cause?

A
  1. Erythema infectiosum (5th disease)

2. Transient aplastic anemia crisis

18
Q

What happens in erythema infectiosum?

A

Affects children between ages 4-12.
A. Fever
B. “Slapped cheek” rash

19
Q

What is useful to remember about PARVOviridae strain B19?

A
  1. Smallest DNA virus
  2. Illness is selflimited
  3. IV immunoglobulin can be used in aplastic crisis