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Flashcards in The Rest of the DNA Viruses Deck (20):
0

What is the morphology of POXviridae?

1. Complex coat
2. Double-stranded linear DNA
3. The only DNA virus to replicate in cytoplasm

1

What can POXviridae cause?

1. Smallpox
2. Molluscum contagiosum

2

What happens in smallpox?

Skin lesions and death - this disease has been eradicated from the earth! :)

3

What happens in molluscum contagiosum?

Small white bumps with a central dimple (like a wart). Often found in the genital region.

4

What is useful to keep in mind about POX-viridae?

1. No animal reservoirs
2. Codes for DNA and RNA polymerases.

5

What is the morphology of PAPOVAviridae?

1. Naked icosahedral
2. Double-stranded circular DNA
3. Replicates in nucleus

6

What are the 3 main pathogenic PAPOVAviridae?

1. HPV
2. BK polyomavirus
3. JC polyomavirus

7

What can HPV cause?

1. Common warts - types 1,2,4,7.
2. Genital warts - types 6,11,16,18 + others.
3. Laryngeal warts - types 6,11.
4. Cervical cancer - types 16,18.

8

What does BK polyomavirus cause?

1. Kidney disease in renal transplant patients.
2. Hemorrhagic cystitis in bone marrow transplant patients, and mild respiratory illness in children.

9

What can JC polyomavirus cause?

Progressive multifocal leukoencephalopathy, characterized by degenerative CNS white matter disease.

10

What are the main methods of wart removal?

1. Liquid nitrogen (freeze them off) - best method.
2. Surgical
3. Electrosurgery (laser ablation)
4. Podophyllin - for genital warts.

11

What is useful to keep in mind about warts?

1. Many warts resolve spontaneously in 1-2 years.
2. Relapses are common after treatment, because HPV DNA is found in normal appearing tissue around the wart.

12

What is interesting to remember about PAPOVAviridae?

Second smallest DNA virus.

13

What is the morphology of ADENOviridae?

1. Naked icosahedral
2. Double-stranded linear DNA
3. Replicates in nucleus

14

What can ADENOviridae cause?

1. Childhood upper respiratory tract infections (rhinitis, sore throat, fever, conjunctivitis).
2. Epidemic keratoconjunctivitis (pink eye).
3. Epidemic diarrheal illness in infants and children.

15

What is important to remember about the problems caused by ADENOviruses?

They are self limited.

16

What is the morphology of PARVOviridae strain B19?

1. Naked icosahedral
2. The only single stranded linear DNA virus (negative stranded).
3. Replicates in nucleus

17

What can PARVOviridae strain B19 cause?

1. Erythema infectiosum (5th disease)
2. Transient aplastic anemia crisis

18

What happens in erythema infectiosum?

Affects children between ages 4-12.
A. Fever
B. "Slapped cheek" rash

19

What is useful to remember about PARVOviridae strain B19?

1. Smallest DNA virus
2. Illness is selflimited
3. IV immunoglobulin can be used in aplastic crisis