Antiviral Drugs Flashcards Preview

Microbiology > Antiviral Drugs > Flashcards

Flashcards in Antiviral Drugs Deck (19):
1

Inhibitors of early events (5)

Amatadine, Rimantadine
Enfuvirtide
Maraviroc
Palivizumab

3

Afftected virus - amantadine

Influenza A

4

Prevents Uncoating (2)

Amantadine & Rimantadine

5

Side effects - amantadine

CNS alterations; dizziness, ataxia, insomnia

6

Alternate drug - amantadine

Rimantadine

7

Affected virus - Enfurvirtide

HIV virus

8

Mechanism - amantadine

Blocks ion channel of M2 matrix proteins; prevents uncoating; no transcription

9

Affected virus - Maraviroc

HIV virus

10

Mechanism - Enfurvirtide

Binds gp41; fusion inhibitor

11

Affected virus - Palivizumab

Respiratory syncytial virus

12

Mechanism - Palivizumab

Monoclonal antibody; binds to fusion protein of virus

13

Uses - Palivizumab

Prevents bronchiolitis & pneumonia in premature and immunocompromised patients

14

Inhibitors of Herpes virus - nucleoside inhibitors (6)

Acyclovir - famciclovir, valacyclovir & penciclovir
Ganciclovir - valganciclovir
Cidofovir
Vidarabine
Idoxuridine
Trifluoridine

15

Inhibitors of Herpes virus - non-nucleoside inhibitors (1)

Foscarnet

16

Mechanism - Acyclovir

Guanosine analog
Monophosphorylated by HSV/VZV encoded THYMIDINE KINASE
Triphosphate formed by Cellular kinases
Inhibits viral DNA polymerase by chain termination

17

Clinical use - Acyclovir

HSV 1&2 and VZV; no CMV
No affect on latent forms

Hsv ---> genital lesions & encephalitis

18

Side effects - Acyclovir

CNS toxicity & renal toxicity (obstructive crystalline nephropathy & acute renal failure)

19

Valacyclovir & famciclovir

Valacyclovir - herpes genitalis & zoster
Famciclovir - herpes zoster

20

Mechanism- Maraviroc

Binds CCR-5; fusion inhibitor; prevents interaction of gp120 with CCR-5; docking inhibitor