2.5 Chemical Mediators of inflammation Flashcards Preview

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Flashcards in 2.5 Chemical Mediators of inflammation Deck (152)
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31

factor 1

proteolytically cleaves C3b

32

C1 inhibitor

binds C1 to inhibit it

33

CD59

inhibits final assembly of MAC

34

C3 deficiency

death from infections if not treated

35

C2 and C4 deficiency

get autoimmune diseases especially lupus

36

MAC deficiencies

get Neisseria infections

37

defect in linking protein linking DAF and VD 59 to RBC

paroxysmal nocturnal hemoglobinuria-->red cells can't defend themselves_.
red cells normally have this linking protein binding this inhibitors of complement so activated complement doesn_t destroy your red cells

38

T cell deficiencies

really strange opportunistic infections

39

Kinin System

Peptieds in the plasma as zymogens

40

factor 12 involved in

the clotting cascade and prekallikrein (protein in plasma) pathway

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factor 12a --> prekallikrein path

prekallikrein --> Kallikrein --> high MW Kiniogin --> Bradykinin

42

Kallikrein

involved in factor 12 regeneration, C5 cleavage to C5a, conversion to Plasmin (by plasminogen)

43

Bradykinin

peptide that acts like histamine

44

Bradykinin causes

inc vascular permeability, vasodilatation of small vessels, pain, contraction of large vessels

45

Coagulation system

factor 12, thrombin, fibrinopeptides generated, factor 10a

46

factor 12

kinin system

47

thrombin

binds protease activated receptors (PARs) on many cells stimulating many inflammatory reactions - if you're making thrombin you're not well so it makes sense to have crosstalk with inflammation, commited step of coagulation cascade

48

Factor 10a (Xa)

directly inflammatory

49

Fibrinolytic System

plasminogen --> plasminogen --> Plasmin

50

Plasmin involved in

C3/5 cleavage, Fibrin split product formation, factor 12a formation

51

activated factor 12(12a) / (XII) activates

kinins, thrombin, plasmin split products, C3a/5a formation via plasmin

52

C3a and 5a are fromed from

classic pathway, alternative pathway, microbes, plasmin

53

arachidonic acid metabolites

lipid in cells that are synthesized

54

Arachidonic acid is a

20 carbon unsaturated fatty acid (5 8 11 14 cicosatetraenoic acid)

55

AA is derived fomr

dietary sources or synthesized form linoleic acid

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In phospholipids AA is

esterified especially at the 2 carbon position of phosphatidyl-choline, inositol and ethanolamine

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different cells will have particular enzymes to creat AA metabolites such as

cyclooxygenases (prostaglandins),
lipooxygenases (leukotrienes)

58

Phospholipases turn

phospholipids into AA

59

Steroids will inhibit

first commited stip shutting down AA synthesis and all its metabolites by extension

60

asprin and NSAIDS

only stop cyclooxygenases