2.5 Chemical Mediators of inflammation Flashcards Preview

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Flashcards in 2.5 Chemical Mediators of inflammation Deck (152)
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91

lipoxins inhibit

vasoconstircion induced by LTC4,
neutrophil chemotaxis and adhsion

92

Lipoxins stimulate

vasodialation,
monocyte activities --> seen in switch from acute to chronic

93

Lipoxins vs leukotrienes relationship

inverse

94

Asprin and NSAIDs inhibit

COX1 and COX2

95

Celebrex inhibits

COX2 and later COX1 _.remeber fda study comparing celebrex and asprin

96

Zileuton inhibits

5LO

97

receptor antagonists for cysteinyl leukotrienes

montelukast (singulari) Zafirlukast, Pranlukast

98

glucocorticosteroids inhibit

phospholipases and downregulate COX2

99

Where is cox1 made

in the stomach - needed to protect against stomach acid

100

How does asprin work

acetylsiacilic acid causes irreversible shut down by acethylating cyclooxygenase

101

asprin also inhibits synthesis of

prostacyclin

102

give low dose asprin to

turn off platelets and prevent coagulation

103

fish oils

have less arachidonic acid and proinflammtory processes aer less

104

PAF - platelet activating factor

is made of lipd found in cells and are synthesized

105

PAF is a bioactive lipid called

acetyl-glyceryl-ether phosphorylcholine - glycerol backbone with long chain fatty acid in A position, short chain in B position and PC in C.
original long FA in B removed by phospholipase A2 then acetylated by acetyltransferase

106

PAF is found in

all infammatory cells and endothelial cells

107

PAF at high concentrations causes

constriction---an invitro arteaffect?

108

PAF at low concentrations causes

dialation, 10000 more potent than histamine

109

PAF induces

platelet aggregation,
leukocyte adhesion,
and chemotaxis,
degranulation,
and oxidative burst

110

PAF binds

a single G-protein coupled receptor

111

PAF in the oxididzed forms is found in

cigarette smokers that enhance platelet,
leukocyte,
and endothelial interactions

112

cytokines and chemokines

are proteins/peptides in cells that are both preformed and synthesized but usually synthesized

113

Interleukins

IL1, IL2 etc

114

Interferons

Type I alpha and beta, type 2 gamma

115

colony stimulating factors

GM-CSF, MCSF, GCSF

116

TNF

alpha and beta

117

TGF

beta

118

inflammatory cytokines

IL1 and TNFalpha and beta

119

IL1 and TNF are secreted by

macrophages

120

TNF beta is secreted by

T cells