4.8 Homeostasis Flashcards Preview

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Flashcards in 4.8 Homeostasis Deck (103)
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91

primary coagulation

aggregation induced by ADP and TXA2 - primary hemostatic plug, coagulation cascade is initiated making thrombin

92

secondary hemostatic plug

thrombin with ADP and TXA2 induces tighter aggregation to irreversibly fused mass of platelets - secondary hemostatic plug

93

primary coagulation stops you from bleeding but

if you distrupt it you'll bleed

94

how do you find out pure platelet fn

form a regulated cut and using a stop watch wait till it stops bleeding - this is the formation of the primary hemostatic plug

95

Platelet binding and aggregation

platelets bind to vWF via surface Gp1b

96

Gp1b deficiency

Bernard - Soulier syndrome

97

adp binds to its receptor and induces platelet aggregation via change in

confromation of Gp2bIIIa

98

Gp2bIIIa bind to

noncleaved fibrinogen and that all liks the platelets together

99

Gp2bIIIa deficiency

Glanzmann thrombasthenia

100

adp receptor antagonsit

clopidogrel (plavix)

101

Plavix

inhibits platelet aggregation via inhibition of the induced conformational change in Gp2bIIIa

102

asprin inhibits

thromboxane production

103

can you give asprin and plavix at the same time

no