4.9 Clotting Cascade Flashcards Preview

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Flashcards in 4.9 Clotting Cascade Deck (109)
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31

Kallikrein activates

12 to 12a

32

12a activates

11 to 11a and cleaves more prekallikrein to more kallikrein

33

11a activates

9 to 9a

34

9a activates

10 to 10a on surface of platelets

35

10 can only be activate by 9 a if

the tenase complex is fromed on the PL layer of the platelet plug

36

tenase complex

8a, 9a, 10, Ca

37

8 is activated by

early fromed thrombin from extrinsic pathway

38

8a is the

receptor for 9a and 10 (cofactor for cleavage of 10 by 9a)

39

2 --> 2a (prothrombin --> thrombin)

10a, 5a, 2, and Ca complex on PL to allow 2 to be cleaved into 2a

40

5a is a cofactor in the formation of 2a similar to

8a in the formation of 10a

41

thrombin activates

8 to 8a

42

function of 8a

a transglutimase that crosslinks fibrinmaing it more stable

43

thrombin activates factors

11, 8, 5, and plays a major role in early platelet activation

44

thrombin also activates

protein C

45

Protein C

in the presence of protein S and PL degrades 5a and 8a --> INHIBITORY PATH

46

antithrombin 3 inhibits

thormbin (major) and 9a, 10a, 11a, 12a

47

heparin enhances

antithrombin 3 activity 1000 fold

48

warfarin/comadin

anticoagulation factor

49

vit K

cofactor in clotting and warfarin inhibits the thing that Vit k binds?

50

Ca is needed for clevage of

11 by 12a, 9 by 11a, 10 by 9a, 2 by 10a

51

5a is needed for

clevage of 2 by 10a

52

PL layer needed to gererate

10a and 2a(thrombin)

53

slide 45

picture of this

54

from which factor onward is there an amplification and crossover of intrinsic and extrinsic paths

9a

55

severe deficiences in which factors do NOT result in serious bleeding

12 and 11

56

Thrombosis

pathological coagulation of blood, number 1 cause of mortality and morbidity in USA

57

Virchow's Triad

endothelial injury,
stasis/turbulence,
hypercoagulability

58

endothelial injury

even just stress and not complete death of endothelial cells can cause change to the phenotype

59

Stasis/turbulence

understand moving stasis - formation of eties

60

hypercoagulability is determined by

genetic and environmental factors