4.9 Clotting Cascade Flashcards Preview

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Flashcards in 4.9 Clotting Cascade Deck (109)
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91

Emboli

detached intravascular solid, liquid, or gas that is cared by blood to a distant site

92

99% of emboli are

are thromboemboli

93

other emboli

nitrogen,
air,
fat,
artherosclerotic plaque

94

Pulmonary thromboembolism

clinically important event and frequent cause of sudden death,
may or maynot cause infarction,
majority from deep leg veins

95

organs least prone to infarction after thromboembolism

lung and
liver

due to collateral blood supply

96

so probability of infarction goes up as you go more

distal

97

in pulmonary thromboembolism sudden death is due to more

proximal events ---- tend to be bigger and kill you

98

in pulmonary thromboembolism, infarction is more likely to occur

in more peripheral (distal?) tissue due to capillary drop off

99

if a clot formd after death

it would fall away from the walls

100

if the lung tissue still looks healthy when you see a pulmonary thromboembolism

this means the person died suddenly with no time to develop disease and destroy tissue

101

difference btw infarct and hemmoragic thromboembolism

infarct is rock hard bc tissue is dead and surrounding blood is pumping into dead tissue, but hemmoragic would be squishy

102

when you start to see organization there are

fibroblasts - tells you that the clot happened a long time ago

103

Fat emboli

occurs after crush injuries to bone where small liquid blobules of fat shower curgulation

104

what does fat do to platelets

activates platelets and injures endothelium leading to thrombosis

105

Amniotic fluid embolism

rare but dangerous bc of the biochemical effects of the amniotic fluid in the mother's blood, and squamous cells and lanugo hair lodge in the mother's pulmonary vessels, sends mother into shock, massive DIC

106

Gas embolisme most frequently occurs as

decompression sickness seen in divers and casson workers

107

to see symptoms of gas embolism need

more than 100cc gas

108

orthepedic surgery and gas emolism

since bone breaks are prone to vessels being exposed to air, air can be sucked into the patient bc the vessels in the bone are held wide open - if enough air comes in it can kill the patient

109

Arterial emboli arise from

most arise from mural thrombi in heart, other form
aneurysms,
artherosclerotic plaques, or
valves