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Flashcards in 4B-3 Deck (18)
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Spongiform encephalopathy

Prions

1

Only Char of prions same with virus

FP
Filterable infectious
Presence of proteins

2

Prototype

Scrapie

3

Difference of prpsc and prpc

Sc:
Multimeric
Location-cytoplasmic

4

How do they cause dse?

Template mediated protein refolding

5

Prpc is encoded in what chromosome

20

6

Strains of prpsc continues how?

Mutate prpc
Self folding of prpsc

7

Determines severity of cjd

Cdon 129

8

Appearance of vacuolated neurons, loss of fcn, no immune

Spongiform enceph

9

Protein marker seen in csf

14-3-3

10

Incubation perood?

Long, 30 yrs

11

Transmission?

Fict
Food
Injection
Contact thru medical dvce
Transplantation

12

Ibheritable dseases

CJD
FFI
GSS

13

Means shivering dse

Kuru

14

Dse w sporadic occurence

Gss
Cjd

15

CharacteriZed by loss of muscle cobtrol, myoclonus, tremors

spongiform enceph

16

Dx of prions

Proteinase K resistant at wblot
PMCA ( initiate polymern of prp)

17

Disinfection??!

HAS
Hypochlorite
AUTOCLAVE
Sodium OH