4-1 Orthomyxo Flashcards Preview

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Flashcards in 4-1 Orthomyxo Deck (44)
0

Antigenically stable

Type C

1

Subtypes are dt antigenic variations of surface glycoproteins

HA
NA

2

LRTI caused by?

Abc
Rsv
Parainfluenza

3

Proteins of ortho

9 sp
1nsp

4

CAuses highly infectious viral illness

Orthomyxo

5

Found in mosquitoes, ticks, and banded mongoose

Thogotovirus

6

7 segments?

C

7

Enveloped?

Yes

8

For Release of virus

Neuraminidase

9

For Core receptor

Nucleoprotein

10

Protein For attachment

Hemaglutinin

11

For regulation of mrna splicing

Ns1 ns2

12

Antiviral drugs target what?

M2 protein

13

Target of neutralizing antibodies

Hemagglutinin

14

Ha causes antigenic changes of what?

Minor drift
Major shift

15

Describe the receptor for HA

Trisaccharide of sialic, gal, glu

16

Neuraminidase is important in determination of what?

Subtypes!

17

THGSY is?

Standard nomenclature

18

Human and animal strains

A

19

Human and swine

C

20

Ha has ? Subtypes?

15

21

Hiw many subtypes of ha and na recovered in humans

4ha
2 na

22

H5n1?

Chickens to humans

23

Shift or drift?
New subtype
Minor
Pandemic

Shift
Drift
Shift

24

Transmission

Inhalation

25

Survives what?

Slow drying
Dust
4c
Seawater
-70c

26

Systemic sx?

Dt interferon and lymphokines

27

Local sx?

Cilia and mucus secreting cells

28

Important for future protection against infection

Antibody

29

Important cause of croup in children Under 1yo

A

30

Gastric flu. Type?

B

31

Afebrile urti. Type?

C

32

Croup is associated with what sx?

Otitis media

33

Lung complications?

PRimary inf pneumonia
Bacterial pneumonia
Cardiac involvment
Neuro (GBS, reyes, enceph)

34

Sequelae that Affects 2-6yo?

Reyes

35

Reyes manifestations

hHiME
Hepato
Hypogly
Mental stat
Inclease bloood ammonia
Enceph

36

Immunity important?

IgA IgG
Celular immunity

37

Antibodies to this is the only way to be protective

Ha and na, others are not

38

T or f? No cross protection to the types?

T

39

Samples best Obtained at what time?

3 days after onset

40

Detects hemadsorbing virus

Hemadsorption

41

Detects virus antigens

Hsf elisa

42

M2 ion channel inhibitors

Rimantidine

43

Ineffective against b and c

A..amantadine