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Flashcards in Poxvirus Deck (47)
0

Largest virus

Pox

1

In EM they appear?

Brickshaped or ellipsoid

2

Replication takes place in

Cytoplasm

3

Released thru?

Lysis ( envelope acquired in the cytoplasm)

4

Etiologic agent of small pox

Variola

5

Dna is rich in whay bases?

AT

6

Used for smallpox vaccines

Vaccinia

7

Describe virion of pox

Core and lateral bodies;
Ridges;
Oval/brickshaped

8

Has low GC content except for

ParaPoxvirus

9

This step requires newly synthesiZed virus

Uncoating

10

Primary hosts are humans

Variol
Vaccinia
Molluscum

11

Difference of variola and vaccinia

Variola has NARROW host range

12

Similarities of variola and vaccinia

Bth grow on culture (egg, animal)
Similar nucleotide

13

______ infection does not occur in variola

Asymptatic

14

Transmision of variola

Resp droplet

15

Types of variola major

OMFH
Ordinary
Modified
Flat
Hemorrhagic

16

What do you call the intracytoplasmic inclusion body of variola?

Guarneri bodies

17

Primary viremia occurs in variola where?

Lymph nodes ( spleen, BM, liver...)

18

Secondary viremia

Skin and mucus membrane

19

Clinical disease of variola

Pre eruptive phase;
Early (6-9thday);
Late

20

Epithelial cells of malphigian layer became swollen and underwent

Balooning defeneration

21

Variola has Similar histopath occurs with vaccinia the difference is...

Localized pustular lesions only

22

Orthopox cannot be diffd in EM w one another, in what genera can it be diffd

Tana and parapox

23

How to diffd orthopox groups?

Embryo chick: vaccinia are large w necrosis; variola are smaller

24

Poxvirus that cannot be cultured?

Molluscum

25

Immune system used by hosts w variola

Cell mediated immunity rather than antibody

26

Effective as prophylaxis for smallpox

Methiazone

27

Order of primary response in vaccinia

Papule
Vesiculation
Pustule
Crust
Pochmark

28

Termed as partial response only; lesions are seen rapidly and less severe

Vaccinoid response

29

Most serious compliacation of vaccinia

CNS disease

30

Most common complication of vaccinia

Inadvertent autoinoculation

31

Vaccinia Contraindicated in?

Pregnant ( fetal vaccinia)

32

Failure of initial lesion to heal and appearance of sec lesion elsewhere

Progressive vaccinia

33

Only diff of monkeypox to orthopox

Cervical and inguinal lymphadenopathy

34

Cowpox Diffd from vaccinia by these lesions on chick embryo

Deep red hemorrhagic lesions

35

Natural reservoir of cowpox

Rodents

36

Autoinoculation to the eyes

Cowpox

37

Painful lesions ( macules, papules, papillomatous)

Parapox orf

38

Milkers nodule virus

Pseudocowpox

39

Painless but itchy ( papules then nodules)

Pseudocowpox

40

2 stages of tanapox disease

Pre eruptive
Eruptive

41

Define pre eruptive of tanapox

Fever, headache, itching

42

Transmission of tanappx?

Vector

43

Transmission of molluscum

Fomites

44

Umbilicated lesions with satellite nodules in molluscum

Asymptomatic lesion

45

Discrete dome shaped waxy papules that changes color from white to pink to yellow in nolluscum

Charracteristic lesion

46

Found from rhesus monkeys

Yaba monkey pox