Poxvirus

Question 0

In EM they appear?

Answer 0

Brickshaped or ellipsoid

Question 1

Largest virus

Answer 1

Pox

Question 2

Replication takes place in

Answer 2

Cytoplasm

Question 3

Released thru?

Answer 3

Lysis ( envelope acquired in the cytoplasm)

Question 4

Etiologic agent of small pox

Answer 4

Variola

Question 5

Dna is rich in whay bases?

Answer 5

AT

Question 6

Used for smallpox vaccines

Answer 6

Vaccinia

Question 7

Describe virion of pox

Answer 7

Core and lateral bodies;
Ridges;
Oval/brickshaped

Question 8

Has low GC content except for

Answer 8

ParaPoxvirus

Question 9

This step requires newly synthesiZed virus

Answer 9

Uncoating

Question 10

Primary hosts are humans

Answer 10

Variol
Vaccinia
Molluscum

Question 11

Difference of variola and vaccinia

Answer 11

Variola has NARROW host range

Question 12

Similarities of variola and vaccinia

Answer 12

Bth grow on culture (egg, animal)

Similar nucleotide

Question 13

______ infection does not occur in variola

Answer 13

Asymptatic

Question 14

Transmision of variola

Answer 14

Resp droplet

Question 15

Types of variola major

Answer 15

OMFH
Ordinary
Modified
Flat
Hemorrhagic

Question 16

What do you call the intracytoplasmic inclusion body of variola?

Answer 16

Guarneri bodies

Question 17

Primary viremia occurs in variola where?

Answer 17

Lymph nodes ( spleen, BM, liver…)

Question 18

Secondary viremia

Answer 18

Skin and mucus membrane

Question 19

Clinical disease of variola

Answer 19

Pre eruptive phase;
Early (6-9thday);
Late

Question 20

Epithelial cells of malphigian layer became swollen and underwent

Answer 20

Balooning defeneration

Question 21

Variola has Similar histopath occurs with vaccinia the difference is…

Answer 21

Localized pustular lesions only

Question 22

Orthopox cannot be diffd in EM w one another, in what genera can it be diffd

Answer 22

Tana and parapox

Question 23

How to diffd orthopox groups?

Answer 23

Embryo chick: vaccinia are large w necrosis; variola are smaller

Question 24

Poxvirus that cannot be cultured?

Answer 24

Molluscum

Question 25

Immune system used by hosts w variola

Answer 25

Cell mediated immunity rather than antibody

Question 26

Effective as prophylaxis for smallpox

Answer 26

Methiazone

Question 27

Order of primary response in vaccinia

Answer 27

``` Papule Vesiculation Pustule Crust Pochmark ```

Question 28

Termed as partial response only; lesions are seen rapidly and less severe

Answer 28

Vaccinoid response

Question 29

Most serious compliacation of vaccinia

Answer 29

CNS disease

Question 30

Most common complication of vaccinia

Answer 30

Inadvertent autoinoculation

Question 31

Vaccinia Contraindicated in?

Answer 31

Pregnant ( fetal vaccinia)

Question 32

Failure of initial lesion to heal and appearance of sec lesion elsewhere

Answer 32

Progressive vaccinia

Question 33

Only diff of monkeypox to orthopox

Answer 33

Cervical and inguinal lymphadenopathy

Question 34

Cowpox Diffd from vaccinia by these lesions on chick embryo

Answer 34

Deep red hemorrhagic lesions

Question 35

Natural reservoir of cowpox

Answer 35

Rodents

Question 36

Autoinoculation to the eyes

Answer 36

Cowpox

Question 37

Painful lesions ( macules, papules, papillomatous)

Answer 37

Parapox orf

Question 38

Milkers nodule virus

Answer 38

Pseudocowpox

Question 39

Painless but itchy ( papules then nodules)

Answer 39

Pseudocowpox

Question 40

2 stages of tanapox disease

Answer 40

Pre eruptive | Eruptive

Question 41

Define pre eruptive of tanapox

Answer 41

Fever, headache, itching

Question 42

Transmission of tanappx?

Answer 42

Vector

Question 43

Transmission of molluscum

Answer 43

Fomites

Question 44

Umbilicated lesions with satellite nodules in molluscum

Answer 44

Asymptomatic lesion

Question 45

Discrete dome shaped waxy papules that changes color from white to pink to yellow in nolluscum

Answer 45

Charracteristic lesion

Question 46

Found from rhesus monkeys

Answer 46

Yaba monkey pox