Neoplasms 1 Flashcards

1
Q

What is a neoplasm?

A
  • An abnormal mass/new (neo-) growth of tissue
  • Growth is not co-ordinated

  • Persists after removal of inciting stimulus (if any is identified)

  • May have secondary changes: e.g. ulceration
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2
Q

Define adenoma

A

A benign epithelial neoplasm that forms glands OR which derives from glandular tissue

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3
Q

Define papilloma

A

A benign epithelial neoplasm characterised by the formation of finger-like projections from the epithelial surface.

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4
Q

Define teratoma

A

A tumour composed of ecto, endo and/or mesoderaml tissues, usually multiple, foreign to the site of origin.

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5
Q

Definae hamartoma

A

A tumour-like malformation composed of differentiated tissues normal to the site of origin. (iris, pulmonary, renal)

NOT a neoplasm

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6
Q

Define blastoma

A

A tumour composed of embryonic cells – very primitive cells

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7
Q

Define choristoma

A

A mass of histologically normal tissue in an abnormal location

NOT a neoplasm

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8
Q

Define polyp

A

Any growth or mass protruding from a mucous surface

It may not be a neoplasm

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9
Q

Define tuberculoma

A

A tumour-like mass resulting from the enlargement of a caseous tubercle.

NOT a neoplasm

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10
Q

Define mycetoma

A

A chronic disease due to infection by various fungus or actinomycetes affecting the foot, hands, legs or internal organs.

NOT a neoplasm.

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11
Q

Define anaplasia

A

A condition of cells in which they have poor cellular differentiation, losing the morphological characteristics of mature cells and their orientation with respect to each other and to endothelial cells.

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12
Q

Define pleomorphism

A

Pleomorphism is a term used in histology and cytopathology to describe variability in the size, shape and staining of cells and/or their nuclei. It is a feature characteristic of malignant neoplasms, and dysplasia.

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13
Q

Define metastasis

A

The development of secondary malignant growths at a distance from a primary site of cancer.

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14
Q

What does carcinoma refer to?

A

Malignant epithelial

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15
Q

What is cancer?

A

Malignant neoplasm

A tumour having the properties of anaplasia, invasiveness and metastasis.

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16
Q

What does sarcoma refer to?

A

Malignant mesenchymal

17
Q

Define dysplasia

A

The enlargement of an organ or tissue by the proliferation of cells of an abnormal type, as a developmental disorder or an early stage in the development of cancer.

18
Q

What factors are used to classify neoplasms?

A
  • Behavioural

  • Histogenetic

  • Descriptive

  • Site of origin
  • Embryological – ecto, endo or mesodermal
  • Aetiological – usually not known
  • Molecular – emerging. I.e. HER 2, BRAF ALK positive
19
Q

What is the difference between benign and malignant?

A

Benign – remains localized

Malignant – not localized. Can be primary or secondary