Haemotology - Coagulation & Consolidation

Question 1

What type of deficiency should you suspect is a mixing study corrects an isolated prolonged clotting time?

Answer 1

A factor deficiency

Question 2

Are a strong bleeding history and normal test results more likely to be a result of abnormalities in primary or secondary haemostasis?

Answer 2

Primary

Question 3

If a patient has a normal APTT/PT, is a severe deficiency in secondary haemostasis likely?

Answer 3

No

Question 4

If a patient has a normal platelet count, could you have an abnormality in primary haemostasis?

Answer 4

Yes - there could be a functional platelet abnormality

Question 5

What does Willebrand’s disease affect?

Answer 5

The body’s ability to clot - time to clot is lengthened because of a deficiency in the von Willebrand factor

Question 6

What could elevated INR and APTT be a result of?

Answer 6

A deficiency in clotting factors in both the intrinsic and extrinsic pathways

Question 7

If fibrinogen looks low on the functional assay, but is slightly high in a total fibrinogen assay, what does this suggest?

Answer 7

Functionally abnormal fibrinogen

Question 8

What would the effects of a Vit K inhibitor have on prothrombin time?

Answer 8

Would prolong prothrombin time, as Vit K inhibition would cause a deficiency in clotting factors 2, 7, 9 and 10

Question 9

Is a disorder of secondary haemostasis likely with a normal INR and APTT + a history of bleeding?

Answer 9

No, it’s more likely to be abnormal primary