Common skin infections Flashcards
Describe the skin as a barrier to infection
- stratum corneum (outermost layer of the epidermis) consists of keratinised cells and is a mechanical barrier to infection
- disruption allows penetration of pathogens into underlying tissue and throughout the body via lymphatics and blood vessels (capillary plexus)
- disruption of mechanical barrier causes inflammation (another barrier to infection = good) although this response can be exaggerated in severe infections (= bad)
IMPETIGO/SCHOOL SORES/PYODERMA
- Symptoms?
- Causes?
- Pathogenesis?
- Investigation?
- Treatment?
Symptoms: red papules, pustules and plaques on arm/hand/face (sometimes confused w/ herpes)
Cause: Group A Strep (S. pyogenes)
Pathogenesis: infection of superficial skin
Investigation: skin swab (gram stain to confirm S. pyogenes)
Treatment: topical antibiotics (fucidin) or oral (fluclox)
Describe the role of venous insufficiency in skin and soft tissue infections
Venous insufficiency is a predisposing factor to cellulitis, erysipelas, chronic venous ulcers and other skin infections.
Describe common cellulitis masquaraders
Lipodermatosclerosis (2ndary to venous stasis), erythema nodosum, pyoderma gangrenosum
Important to treat underlying cause - not based on the symptoms, as these can be common between cellulitis and its masquaraders
TINEA
- Symptoms?
- Causes?
- Pathogenesis?
- Investigation?
- Treatment?
Symptoms: itchy, burning skin; thick, crumbly, discoloured nails
Causes: dermatophyte infection, many species (most common is T. rubum)
Patho.: fungi invade epidermis and cause inflammation by producing keratinases. Can be at different sites of the body (tinea pedis = feet; tinea corporis = body; tinea cruris = creases; tinea capitis = scalp; tinea unguium = nail; tinea versicolour = mostly trunk hyper/hypopigmentation)
Invest.: skin scraping (from edge of advancing lesion) or nail clipping –> microscopy and culture
Treatment: antifungals
PARONYCHIA (bacterial)
- Symptoms?
- Causes?
- Pathogenesis?
- Investigation?
- Treatment?
Symp: painful, red, swollen fingernail
Causes: Staph. aureus
Patho.: soft tissue infection around fingernail from breakdown of protective barrier bw nail and nail fold
Invest.: nil outlined
Treatment: soak w/ warm water, oral antibiotics (augmentin or clindamycin), drainage of pus
CHRONIC PARONYCHIA (fungal)
- Symptoms?
- Causes?
- Pathogenesis?
- Investigation?
- Treatment?
Symp: > 6wks of inflammation, pain, swelling
Causes: Candida albicans
Patho: fungal invasion associated with water/damp skin
Invest: nil outlined
Treat: keep dry, warm soaks, topical antifungals
DACTYLITIS
- Symptoms?
- Causes?
Symp: sausage shaped, painful, swollen fingers and toes
Causes: Grp A Strep (also seen in sickle cell anaemics)
BULLOUS IMPETIGO
- Symptoms?
- Causes?
- Pathogenesis?
- Treatment?
Symp: fluid filled blisters that pop and leave sores
Causes: S. aureus
Patho: S. aureus produces toxins which can spread locally or generally (depending on the host immune system - maternal antibodies). General spread = staph scalded skin syndrome (SSSS)
Treat: fluclox + vancomycin
FOLLICULITIS
- Symptoms?
- Causes?
- Pathogenesis?
- Treatment?
Symp: itchy, papules w/ central pustule
Causes: usually S. aureus (eg. folliculitis barbae - think barber –> dry shaving beard spreads S.aureus into tiny cuts), possibly P. aeruginosa (hot tub folliculitis) or Candida
Patho: infection of hair follicles/apocrine glands
Invest: where there is pus, there is swab
Treat: local (saline), topical antibiotics and/or antifungal
FURUNCLES/BOILS
- Symptoms?
- Causes?
- Pathogenesis?
- Investigation?
- Treatment?
Symp: deep inflammatory nodule usually in friction/sweaty areas containing follicles (neck, face, underarm/axillae, butt)
Causes: usually S. aureus
Patho: spread of folliculitis to deeper tissues, predisposed by obesity and immunosuppression
Invest: where there is pus, there is swab
Treat: warm soaks, anti-staph antibiotics (fluclox, vanco), prophylaxis for recurrent boils (general hygiene, Staph decolonisation w rifampicin and ciprofloxacin)
CARBUNCLE/CLUSTER OF BOILS
- Symptoms?
- Causes?
- Pathogenesis?
- Investigation?
- Treatment?
Symp: recurrent boils, painful discharging lesions, fever, deep infection, usually neck, back or thighs
Causes: usually S. aureus
Patho: Folliculitis spreads to furuncles then forms clusters/carbuncles, can have surrounding infection (cellulitis) and spread to blood (bacteraemia)
Invest: where there is pus, there is swab
Treat: surgical drainage, antibiotics (fluclox + vanco)
ERYSIPELAS/RED FACE
- Symptoms?
- Causes?
- Pathogenesis?
- Investigation?
- Treatment?
Symp: red rash w/ clearly defined borders (demarcated borders)
Causes: usually Group A Step.
Patho: superficial bacterial skin infection involving cutaneous lymphatics, predisposed by other factors (tinea, venous insufficiency)
Invest: look for other infections or conditions (tinea etc)
Treat: penicillin
CELLULITIS
- Symptoms?
- Causes?
- Pathogenesis?
- Investigation?
- Treatment?
Symp: diffuse spreading erythematous rash (vs erysipelas which has defined borders); inflammation - heat, red, swelling, pain; lymphadenopathy/lymphadenitis, fevers, chills
Causes: S. aureus or beta haemo strep
Patho: acute bacterial infection of skin and soft tissues predisposed by other factors (tinea pedis, skin diseases, leg oedema, immunodeficiency)
Invest: swab blister fluid but could be misleading because of colonisers
Treat: antibiotics (fluclox, cephalexin, clindamycin)