Chronic Inflammation

Question 1

What cell types are involved in chronic inflammation

Answer 1

Macrophages
Plasma cells
Lymphocytes
Fibroblasts

Question 2

What is the outcome of chronic inflammation

Answer 2

features tissue or organ damage, (necrosis)

Question 3

What is the clinical presentations of chronic inflammation

Answer 3

Loss of function
Weight loss
Not a specific sore bit

Question 4

What are the two ways chronic inflammation appears

Answer 4

arising from acute inflammation

arising as a primary lesion

Question 5

What are the steps in granulation tissue

Answer 5

Capillaries grow into mass
Plasma proteins (platelts)
Macrophages come from blood and tissue
fibroblasts lay down collagen to repair damaged tissue
crosslinking occurs pulling skin tighter together - narrowing
forming scar

Question 6

When can fibrosis become a problem

Answer 6

Leads to chronic inflammation

Loss of functions in organs

Question 7

What is granulation an outcome of and what can it lead to

Answer 7

Acute inflammation that can lead to Chronic inflammation

Question 8

What are examples of chronic inflammation from acute inflammation

Answer 8

Acne
Cholecystitis (inflammation of the gall bladder) 
Peptic ulcer 
Osteomyelitis (abscess in the bone) 
Fracture healing

Question 9

How can chronic inflammation occur as a primary lesion

Answer 9

Due to autoimmune disease, as auto antibodies are directed against own cell tissue

Question 10

Examples of autoimmune disease chronic inflammation

Answer 10

Thyroiditis,
Rheumatoid disease
Foreign body

Question 11

What are factors that can cause primary chronic inflammatory response but not an immune response

Answer 11

material resistant to digestion
exogenous substances (eg sutures, hip replacement)
endogenous substances (eg. keratin, necrotic tissue)
granulomata inflammation